Biochemistry 4th Edition by Reginald Garrett, Charles Grisham

Exercise 10

One way negative cooperativity might make metabolic sense
Allosteric enzymes that sit at branch points leading to several essential products sometimes display negative cooperativity for feedback inhibition (allosteric inhibition) by one of the products. What might be the advantage of negative cooperativity instead of positive cooperativity in feedback inhibitor binding to such enzymes