Biochemistry 4th Edition by Reginald Garrett, Charles Grisham

Exercise 7

Analyzing the succinate dehydrogenase reaction
Of the dehydrogenase reactions in glycolysis and the TCA cycle, all but one use NAD+ as the electron acceptor. The lone exception is the succinate dehydrogenase reaction, which uses FAD, covalently bound to a flavoprotein, as the electron acceptor. The standard reduction potential for this bound FAD is in the range of 0.003 to 0.091 V (Table 3.5). Compared to the other dehydrogenase reactions of glycolysis and the TCA cycle, what is unique about succinate dehydrogenase Why is bound FAD a more suitable electron acceptor in this case