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Biochemistry 4th Edition by Reginald Garrett, Charles Grisham
Edition 4ISBN: 9780495109358Biochemistry 4th Edition by Reginald Garrett, Charles Grisham
Edition 4ISBN: 9780495109358 Exercise 17
Modeling the LDL receptor
In the LDL receptor structure shown in Figure 24.41c, the -propeller interaction with domains R4 and R5 is partly stabilized by salt bridges between acidic residues on R4 and R5 that also coordinate Ca2+ ions. Use a molecular modeling program or consult the literature to identify at least two such interactions. Two suitable references are Beglova, N., and Blacklow, S. C., 2005. Trends in Biochemical Sciences 30:309-316; and Rudenko, G., Henry, L., et al., 2002. Science 298:2353-2358.
In the LDL receptor structure shown in Figure 24.41c, the -propeller interaction with domains R4 and R5 is partly stabilized by salt bridges between acidic residues on R4 and R5 that also coordinate Ca2+ ions. Use a molecular modeling program or consult the literature to identify at least two such interactions. Two suitable references are Beglova, N., and Blacklow, S. C., 2005. Trends in Biochemical Sciences 30:309-316; and Rudenko, G., Henry, L., et al., 2002. Science 298:2353-2358.
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LDL is a multi-domain, single pass trans...
Biochemistry 4th Edition by Reginald Garrett, Charles Grisham
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