Biochemistry 4th Edition by Christopher Mathews,Kensal van Holde, Dean Appling, Spencer Anthony Cahill

Exercise 7

Assume that some protein molecule, in its folded native state, has one favored conformation. But, when it is denatured, it becomes a "random coil," with many possible conformations.
(a) What must be the sign of AS for the change: native denatured
(b) How will the contribution of AS for native denatured affect the favorability of the process What apparent requirement does this impose on H if proteins are to be stable structures