Biochemistry 4th Edition by Christopher Mathews,Kensal van Holde, Dean Appling, Spencer Anthony Cahill

Exercise 9

It is observed that as temperature is increased, most protein molecules go from their defined, folded state into a random-coil, denatured state which exposes more hydrophobic surface area than is exposed in the folded state.
(a) Given what you have learned so far about H and S , explain why this is reasonable. [Hint: Consider Problem 7.]
(b) Sometimes, however, proteins denature as temperature is decreased. How might this be explained [Hint: Consider Problem 8.]