Biochemistry 4th Edition by Christopher Mathews,Kensal van Holde, Dean Appling, Spencer Anthony Cahill

Exercise 16

Suppose the concentration of glucose inside a cell is 0.1 mM and the cell is suspended in a glucose solution of 0.01 mM.
(a) What would be the free energy change involved in transporting 10 6 mole of glucose from the medium into the cell Assume T = 37 °C.
(b) What would be the free energy change involved in transporting 10 6 mole of glucose from the medium into the cell if the intracellular and extracellular concentrations were 1 mM and 10 mM, respectively
(c) If the processes described in parts (a) and (b) were coupled to ATP hydrolysis, how many moles of ATP would have to be hydrolyzed in order to make each process favorable (Use the standard free energy change for ATP hydrolysis.)