Biochemistry 4th Edition by Christopher Mathews,Kensal van Holde, Dean Appling, Spencer Anthony Cahill

Exercise 10

Some anaerobic bacteria use an alternative pathway for glucose catabolism, shown below, that converts glucose to acetate rather than to pyruvate. The first part of this pathway (glucose to fructose-1,6-bisphosphate) is identical to the glycolytic pathway. In the second part of the alternative pathway, Enzymes 1-6 all have mechanisms/activities analogous to enzymes in glycolysis. Note that there are two C-C bond cleavage reactions in this new pathway: A B + C (Enzyme 1 ) and C B + D. All the steps where ATP is consumed or generated have been shown; however, the addition or