Biochemistry 4th Edition by Christopher Mathews,Kensal van Holde, Dean Appling, Spencer Anthony Cahill

Exercise 5

Signaling molecules interact with cells through specific macromolec-ular receptors. For each of the four receptors identified below, list all characteristics, by number, which accurately describe that receptor.
(a) an adrenergic receptor______________
(b) a steroid receptor______________
(c) the LDL receptor______________
(d) the insulin receptor______________
1. Located at the cell surface
2. Associated with the protein clathrin
3. Ligand binding stimulates the activity of phospholipase C
4. A transmembrane protein
5. A DNA-binding protein
6. Located in the cell interior
7. Receptor-ligand complex moves to the lysosome
8. Receptor-ligand complex becomes concentrated in the nucleus
9. Receptor activation can inhibit the synthesis of glycogen
10. The hormone-receptor complex activates specific gene transcription
11. Internalization decreases the synthesis of cholesterol esters
12. Action of this receptor diminishes the synthesis and activity of -hydroxy- -methylglutaryl-CoA reductase (HMG-CoA reductase)
13. This receptor activates its own synthesis
14. Biological activity of this receptor involves interaction with guanine nucleotide-binding proteins
15. This receptor has a protein kinase activity
16. Not known to act through a second messenger