Molecular Biology 5th Edition by Robert Weaver

Exercise 2

Predict the effects of the following mutations on the abundance of the TfR mRNA. That is, would the mutations result in a constitutively low or high level of the TfR mRNA regardless of iron concentration, or would they have no effect on the mRNA level
a. A mutation that blocks the production of aconitase.
b. A mutation that prevents aconitase from binding iron.
c. A mutation that prevents aconitase from binding to the IREs.