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iGenetics 3rd Edition by Peter Russell
Edition 3ISBN: 978-0321569769iGenetics 3rd Edition by Peter Russell
Edition 3ISBN: 978-0321569769 Exercise 7
What is a single orphan gene ? What is an orphan family ?
b. In humans, the full name of the RORC gene is RAR-related orphan receptor C. A BLAST analysis of the RORC amino acid sequence reveals a protein withtwo domains, a zf-C4 domain (a DNA-binding domainthat contains a protein motif known as a zincfinger) and a HOLI domain (a ligand-binding domainfound in hormone receptors). The RORC gene is similarto a gene in mice that is essential for the formation of lymphoid tissue. Given all of this information,why do you think the RORC gene might still be consideredto be an orphan gene?
b. In humans, the full name of the RORC gene is RAR-related orphan receptor C. A BLAST analysis of the RORC amino acid sequence reveals a protein withtwo domains, a zf-C4 domain (a DNA-binding domainthat contains a protein motif known as a zincfinger) and a HOLI domain (a ligand-binding domainfound in hormone receptors). The RORC gene is similarto a gene in mice that is essential for the formation of lymphoid tissue. Given all of this information,why do you think the RORC gene might still be consideredto be an orphan gene?
Explanation
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(a)If a gene has an open reading frame (...
iGenetics 3rd Edition by Peter Russell
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