Becker's World of the Cell 9th Edition by Lewis Kleinsmith, Jeff Hardin, Gregory Paul Bertoni

Exercise 8

Regulation of Catabolism. Explain the advantage to the cell of each of the following regulatory mechanisms.
(a)Isocitrate dehydrogenase (Figure 10-8, Reaction TCA-3)is allosterically activated by ADP.
(b)The dehydrogenases that oxidize isocitrate, -ketoglutarate, and malate (Reactions TCA-3, TCA-4, and TCA-8)are all allosterically inhibited by NADH.
(c)Pyruvate dehydrogenase (Figure 10-8, Reaction 10-1, page 261)is allosterically inhibited by ATP.
(d)Phosphofructokinase (Figure 9-7, Reaction Gly-3)is allosterically inhibited by citrate.
(e)Pyruvate dehydrogenase kinase (Figure 10-10, enzyme E 1 )is allosterically activated by NADH.
(f) -ketoglutarate dehydrogenase (Figure 10-8, Reaction TCA-4)is allosterically inhibited by succinyl CoA.