Becker's World of the Cell 9th Edition by Lewis Kleinsmith, Jeff Hardin, Gregory Paul Bertoni

Exercise 9

Protein Folding. The role of BiP in protein folding was briefly described in this chapter. Answer the following questions about observations and situations involving BiP.
(a)BiP is found in high concentration in the lumen of the ER but is not present in significant concentrations elsewhere in the cell. How do you think this condition is established and maintained
(b)If the gene coding for BiP acquires a mutation that disrupts the protein's binding site for hydrophobic amino acids, what kind of impact might this have on the cell