Biochemistry 6th Edition by Reginald Garrett,Charles Grisham

Exercise 23

Assessing How Transmembrane ? -helices are Different. Transmembrane ? -helices have a higher content of hydrophobic amino acids and a lower content of charged and highly polar residues than ? -helices in soluble proteins. These differences have consequences for the structure of these helices. Consult the following references and summarize novel structural features of transmembrane ? -helices (Cross, T.A., Sharma, M., Yi, M., and Zhou, H.-X., 2014. Influence of solubilizing environments on membrane protein structures. Trends in Biochemical Sciences 36 :117-125; Page, R. C. Kim, S., and Cross, T. A., 2008- Transmembrane helix uniformity examined by spectral mapping of torsion angles. Structure 16 :787-797.)