Biochemistry 6th Edition by Reginald Garrett,Charles Grisham

Exercise 27

Exploring Lipopolysacchaide Transport in a Gram-Negative Bacterium Gram-negative bacteria have a cell wall which includes an outer membrane adorned with a tightly packed layer of lipopolysaccharide (LPS) molecules. How are these LPS molecules transported to the outer membrane? Consult the following references and describe the details of LPS transport and the membrane structures that are involved in this transport. (Bishop, R. E., 2014. Lipopolysaccharide rolls out the barrel. Nature 511 :37-38; Dong, H., Xiang, Q., Gu, Y., et al., 2014. Structural basis for outer membrane lipopolysaccharide insertion. Nature 511 :52-57; Qiao. S., Luo, Q., Zhao, Y., et al., 2014. Structural basis for lipopolysaccharide insertion in the bacterial outer membrane. Minor Nature 511 :108-111.