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Biology: Concepts and Investigations 2nd Edition by Mariëlle Hoefnagels
Edition 2ISBN: 978-0077295349Biology: Concepts and Investigations 2nd Edition by Mariëlle Hoefnagels
Edition 2ISBN: 978-0077295349 Exercise 52
In a disorder called gyrate atrophy, cells in the retina begin to degenerate in late adolescence, causing night blindness that progresses to blindness. The cause is a mutation in the gene that encodes an enzyme, ornithine aminotransferase (OAT). Researchers sequenced the OAT gene for five patients with the following results:
• Patient A: A change in codon 209 of UAU to UAA
• Patient B: A change in codon 299 of UAC to UAG
• Patient C: A change in codon 426 of CGA to UGA
• Patient D: A two-nucleotide deletion at codons 64 and 65 that results in a UGA codon at position 79
• Patient E: ExoN6, including 1071 nucleotides, is entirely deleted.
a. Which patient(s) have a frameshift mutation?
b. How many amino acids is patient E missing?
c. Which patient(s) will produce a shortened protein?
• Patient A: A change in codon 209 of UAU to UAA
• Patient B: A change in codon 299 of UAC to UAG
• Patient C: A change in codon 426 of CGA to UGA
• Patient D: A two-nucleotide deletion at codons 64 and 65 that results in a UGA codon at position 79
• Patient E: ExoN6, including 1071 nucleotides, is entirely deleted.
a. Which patient(s) have a frameshift mutation?
b. How many amino acids is patient E missing?
c. Which patient(s) will produce a shortened protein?
Explanation
Verified
Verified
a) patient D
b) 35...
Biology: Concepts and Investigations 2nd Edition by Mariëlle Hoefnagels
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