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Essentials of Genetics 9th Edition by Michael Palladino William Klug, Michael Cummings, Charlotte Spencer
Edition 9ISBN: 978-1292108865Essentials of Genetics 9th Edition by Michael Palladino William Klug, Michael Cummings, Charlotte Spencer
Edition 9ISBN: 978-1292108865 Exercise 1
Zigs and zags of the smallpox virus
Smallpox, a once highly lethal contagious disease, has been eradicated worldwide. However, research continues with stored samples of variola, the smallpox virus, because it is a potential weapon in bioterrorism. Human cells protect themselves from the variola virus (and other viruses) by activating genes that encode protective proteins. It has recently been discovered that in response to variola, human cells create small transitory stretches of Z-DNA at sites that regulate these genes. The smallpox virus can bypass this cellular defense mechanism by specifically targeting the segments of Z-DNA and inhibiting the synthesis of the protective proteins. This discovery raises some interesting questions:
What is unique about Z-DNA that might make it a specific target during viral infection?
Smallpox, a once highly lethal contagious disease, has been eradicated worldwide. However, research continues with stored samples of variola, the smallpox virus, because it is a potential weapon in bioterrorism. Human cells protect themselves from the variola virus (and other viruses) by activating genes that encode protective proteins. It has recently been discovered that in response to variola, human cells create small transitory stretches of Z-DNA at sites that regulate these genes. The smallpox virus can bypass this cellular defense mechanism by specifically targeting the segments of Z-DNA and inhibiting the synthesis of the protective proteins. This discovery raises some interesting questions:
What is unique about Z-DNA that might make it a specific target during viral infection?
Explanation
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Z-DNA has left handed double helix struc...
Essentials of Genetics 9th Edition by Michael Palladino William Klug, Michael Cummings, Charlotte Spencer
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