Essentials of Genetics 9th Edition by Michael Palladino William Klug, Michael Cummings, Charlotte Spencer

Exercise 3

In studies of frameshift mutations, Crick, Barnett, Brenner, and Watts-Tobin found that either three nucleotide insertions or deletions restored the correct reading frame. (a) Assuming the code is a triplet, what effect would the addition or loss of six nucleotides have on the reading frame? (b) If the code were a sextuplet (consisting of six nucleotides), would the reading frame be restored by the addition or loss of three, six, or nine nucleotides?