Essentials of Genetics 9th Edition by Michael Palladino William Klug, Michael Cummings, Charlotte Spencer

Exercise 13

A short RNA molecule was isolated that demonstrated a hyperchromic shift indicating secondary structure (see p. in Chapter). Its sequence was determined to be
5?-AGGCGCCGACUCUACU-3?
(a) Propose a two-dimensional model for this molecule.
(b) What DNA sequence would give rise to this RNA molecule through transcription?
(c) If the molecule were a tRNA fragment containing a CGA anticodon, what would the corresponding codon be?
(d) If the molecule were an internal part of a message, what amino acid sequence would result from it following translation? (Refer to the code chart in Figure.)FIGURE The coding dictionary. AUG encodes methionine, which initiates most polypeptide chains. All other amino acids except tryptophan, which is encoded only by UGG, are encoded by two to six triplets. The triplets UAA , UAG, and UGA are termination signals and do not encode any amino acids.