Molecular Biology of the Gene 7th Edition by Richard Losick, James Watson, Michael Levine, Tamara Baker, Alexander Gann

Exercise 15

Researchers found that a single amino acid change of cysteine to tryptophan in a transmembrane protein causes retinal degeneration. Give the relevant sequence of the mRNA that encodes this substitution. Give the wild-type mRNA sequence(s) and the mutated sequence. Is the amino acid substitution caused by a transition or transversion mutation in the DNA?