Genetics - Analysis and Principles 3rd Edition by Robert Brooker

Exercise 2

Let's suppose a researcher conducted comparative genomic hybridization (see Figure 8.9) and accidentally added twice as much (red) DNA from normal cells. What green-to-red ratio would you expect in a region from a chromosome from a cancer cell that carried a duplication on both chromosomal copies What ratio would be observed for a region that was deleted on just one of the chromosomes from cancer cells
Figure 8.9 The use of comparative genomic hybridization to detect deletions and duplications in cancer cells.
Starting materials: Breast cancer cells and normal cells.