Campbell Biology 11th Edition by Lisa Urry,Michael Cain,Steven Wasserman,Peter Minorsky,Jane Reece

Exercise 10

INTERPRET THE DATA Phosphofructokinase is an enzyme that acts on fructose 6-phosphate at an early step in glucose breakdown. Regulation of this enzyme controls whether the sugar will continue on in the glycolytic pathway. Considering this graph, under which condition is phosphofructokinase more active Given what you know about glycolysis and regulation of metabolism by this enzyme, explain the mechanism by which phosphofructokinase activity differs depending on ATP concentration. Explain why it makes sense that regulation of this enzyme has evolved so that it works this way.