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Molecular Biology Of The Cell 6th Edition by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Edition 6ISBN: 978-0815345244Molecular Biology Of The Cell 6th Edition by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Edition 6ISBN: 978-0815345244 Exercise 2
Discuss the following problems.
-The KDEL receptor must shuttle back and forth between the ER and the Golgi apparatus to accomplish its task of ensuring that soluble ER proteins are retained in the ER lumen. In which compartment does the KDEL receptor bind its ligands more tightly? In which compart- ment does it bind its ligands more weakly? What is thought to be the basis for its different binding affinities in the two compartments? If you were designing the system, in which compartment would you have the highest concentration of KDEL receptor? Would you predict that the KDEL receptor, which is a transmembrane protein, would itself possess an ER retrieval signal?
-The KDEL receptor must shuttle back and forth between the ER and the Golgi apparatus to accomplish its task of ensuring that soluble ER proteins are retained in the ER lumen. In which compartment does the KDEL receptor bind its ligands more tightly? In which compart- ment does it bind its ligands more weakly? What is thought to be the basis for its different binding affinities in the two compartments? If you were designing the system, in which compartment would you have the highest concentration of KDEL receptor? Would you predict that the KDEL receptor, which is a transmembrane protein, would itself possess an ER retrieval signal?
Explanation
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The argument of extraordinary mutation resistance of the genetic code is favor to the forces of natural selection. But it is more reasonable to say that the genetic code is favor or resistance to mutations or frozen accident. This is because the organisms are more comfortable in maintaining enough data to identify complex phenotypes. This reason makes frozen accidents to be more favorable towards the resistance to mutations of genetic code. In addition, it is not a simple argument to support the life form because the resistance to mutation supports higher animals like humans to maintain genetic code to produce complexity of life. But this would reveal only error resistant codes that are limited to frozen accidents. It leads to reduction of the complexity of life by giving rise to more error-prone codes. Thus, it is related with an anothropic principle of cosmology, which says that many universes exist but only few are worthy of living. So, these examples reveal that code is not static but also responds to forces of selection. For example: Genomes of mitochondria and nucleus for most of the organisms are found with mutated versions of genetic code.
Molecular Biology Of The Cell 6th Edition by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
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