
Molecular Biology Of The Cell 6th Edition by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Edition 6ISBN: 978-0815345244
Molecular Biology Of The Cell 6th Edition by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Edition 6ISBN: 978-0815345244 Exercise 6
Discuss the following problems.
-The yeast cohesin subunit Scc1, which is essen- tial for sister-chromatid cohesion, can be artificially regulated for expression at any point in the cell cycle. If expression is turned on at the beginning of S phase, all the cells divide satisfactorily and survive. By contrast, if Scc1 expression is turned on only after S phase is completed, the cells fail to divide and they die, even though Scc1 accumulates in the nucleus and interacts efficiently with chromosomes. Why do you suppose that cohesin must be present during S phase for cells to divide normally?
-The yeast cohesin subunit Scc1, which is essen- tial for sister-chromatid cohesion, can be artificially regulated for expression at any point in the cell cycle. If expression is turned on at the beginning of S phase, all the cells divide satisfactorily and survive. By contrast, if Scc1 expression is turned on only after S phase is completed, the cells fail to divide and they die, even though Scc1 accumulates in the nucleus and interacts efficiently with chromosomes. Why do you suppose that cohesin must be present during S phase for cells to divide normally?
Explanation
The highly conserve nature of ribosomal ...
Molecular Biology Of The Cell 6th Edition by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
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