Molecular Biology Of The Cell 6th Edition by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter

Exercise 13

The enzyme hexokinase adds a phosphate to D-glucose but ignores its mirror image, L-glucose. Suppose that you were able to synthesize hexokinase entirely from D-amino acids, which are the mirror image of the normal L-amino acids. a. Assuming that the "D" enzyme would fold to a sta- ble conformation, what relationship would you expect it to bear to the normal "L" enzyme? b. Do you suppose the "D" enzyme would add a phosphate to L-glucose, and ignore D-glucose?