Molecular Biology Of The Cell 6th Edition by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter

Exercise 12

2 Consider a signaling pathway that proceeds through three protein kinases that are sequentially acti- vated by phosphorylation. In one case, the kinases are held in a signaling complex by a scaffolding protein; in the other, the kinases are freely diffusible (Figure Q15-1). Discuss the properties of these two types of organization in terms of signal amplification, speed, and potential for cross-talk between signaling pathways.