Molecular Biology Of The Cell 6th Edition by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter

Exercise 1

Working out the rules by which T cells interact with their target cells was complicated. Some of the key observations came from studying the way cytotoxic T cells killed cells infected with choriomeningitis virus (LCMV). Cytotoxic T cells derived from mice expressing "k-type" class I MHC proteins lysed LCMV-infected cells express- ing the same k-type MHC protein, but they did not lyse infected cells from mice expressing "d-type" class I MHC proteins (Figure Q24-2). Similarly, cytotoxic T cells from d-type mice lysed infected d-type cells, but not infected k-type cells. LCMV can kill both k-type and d-type mice.