Molecular Biology Of The Cell 6th Edition by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter

Exercise 3

0 At first glance, it would seem a dangerous strategy for the thymus to actively promote the survival, matura- tion, and emigration of developing T cells that bind weakly to self peptides bound to self MHC molecules. Would it not be safer to get rid of these T cells, along with those that bind strongly to such self-peptide-MHC complexes, as this would seem a more secure way to avoid autoimmune reac- tions?