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Bioprocess Engineering 2nd Edition by Fikret Kargi,Michael Shuler
Edition 2ISBN: 9780130819086Bioprocess Engineering 2nd Edition by Fikret Kargi,Michael Shuler
Edition 2ISBN: 9780130819086 Exercise 11
A continuous culture system is being constructed. The fermentation tank is to be 50,000 l in
size and the residence time is to be 2 h. A continuous sterilizer is to be used. The unsterilized
medium contains
spores/l. The value of 
has been determined to be 
at 121∞C
and
at 140∞C. For each temperature (121∞C and 140∞C), determine the required res-
idence time in the holding section so as to ensure that 99% of the time four weeks of continu-
ous operation can be obtained without contamination (due to contaminants in the liquid
medium).
size and the residence time is to be 2 h. A continuous sterilizer is to be used. The unsterilized
medium contains
spores/l. The value of has been determined to be at 121∞Cand
at 140∞C. For each temperature (121∞C and 140∞C), determine the required res-idence time in the holding section so as to ensure that 99% of the time four weeks of continu-
ous operation can be obtained without contamination (due to contaminants in the liquid
medium).
Explanation
Verified
Verified
According to the given data a continuous...
Bioprocess Engineering 2nd Edition by Fikret Kargi,Michael Shuler
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