Question 1

SEDDSs emulsify spontaneously to produce fine oil in water emulsions when introduced into an aqueous phase under gentle agitation and spread readily in the____________.

Accepted Answer

A)  GIT
B)  RT
C)  UT
D)  Liver A

Question 2

Problems with opioid TDDS include.

Accepted Answer

A)  Poor patient compliance
B)  Allergy
C)  Constipation.
D)  Respiratory depression. B

Question 3

A physical method of permeation enhancement that involves the use of high frequency ultrasound. It is thought to influence the integrity of the SC and thus affect its penetrability.

Accepted Answer

A)  Iontophoresis
B)  Sonophoresis
C)  Electrophoresis
D)  Ion exchange B

Question 4

What are the characteristics of the monolithic devices?

Accepted Answer

A)  The drug has a large therapeutic index
B)  Aqueous solution
C)  Control drug release by partitioning the drug from oil
D)  Administration of emulsion

Question 5

TDDS is usually only suitable for drugs of what level of potency?

Accepted Answer

A)  Typically only for drugs of high potency.
B)  Low potency
C)  High to low potency
D)  Low to high potency

Question 6

Which of the following is false for Merits of the TDDS.

Accepted Answer

A)  Avoidance of the First pass effect
B)  A stable and controlled blood level
C)  Termination at any time is conceivable
D)  Skin irritation and allergic response

Question 7

How much thickness of the dermis layer?

Accepted Answer

A)  2 to 7 nm
B)  3 to 5 nm
C)  3 to 6 nm
D)  5 to 8 nm

Question 8

Which of the following characteristics is suitable for transdermal drug?

Accepted Answer

A)  Large drug dose
B)  Large molecular size
C)  Drugs with narrow therapeutic index
D)  Drug which are metabolized in the skin

Question 9

What are the characteristics of the reservoir or membrane devices?

Accepted Answer

A)  The drug has a large therapeutic index
B)  Drug permeation rate is high
C)  Control drug release by partitioning the drug from oil
D)  Administration of emulsion

Question 10

A method of permeation enhancement that involves the use of charged chemical components across the skin membrane using an electric field.

Accepted Answer

A)  Iontophoresis
B)  Sonophoresis
C)  Electrophoresis
D)  Ion exchange

Question 11

Regarding the skin:

Accepted Answer

A)  The epidermis is the thickest layer.
B)  The stratum corneum is the greatest barrier to transdermal transport.
C)  The dermis has a rich capillary blood supply.
D)  Skin hydration is a cause of inter-individual variation in drug absorption.

Question 12

Which of the following is true for monolithic devices?

Accepted Answer

A)  These devices are used when the drug permeation rate is rapid
B)  The release of the drug is controlled
C)  Suitable for drugs with large therapeutic index
D)  The drug is contained in a powder form floating on liquid

Question 13

SEDDSs produce emulsion with droplet size between ____________.

Accepted Answer

A)  200 to 400nm
B)  100 to 300nm
C)  10 to 100nm
D)  1000nm

Question 14

What are the characteristics of the mixed monolithic reservoir devices?

Accepted Answer

A)  The drug has a large therapeutic index
B)  Drug permeation rate is high
C)  The drug polymer matrix is layered by rate controlling membrane
D)  Administration of emulsion

Question 15

Which component are not included in combination of the SEDDS formulation?

Accepted Answer

A)  Oil
B)  Lipid
C)  Drug
D)  Wax

Question 16

Self micro emulsifying drug delivery systems (SMEDDSs) form transparent micro emulsions with droplet size of less than__________.

Accepted Answer

A)  50 nm
B)  70 nm
C)  100 nm
D)  200 nm

Question 17

In the use of TDDS for drug application ? size has to be considered reasonable?

Accepted Answer

A)  Strip size
B)  Patch size
C)  Film size
D)  Diskette size

Question 18

The absorption of the ophthalmic drug does not depend on which of the following?

Accepted Answer

A)  Physicochemical properties of permeating molecule
B)  Drainage of tears
C)  Output of tears
D)  Size of the eyeball

Question 19

Which of the following is false in regarding reservoir devices?

Accepted Answer

A)  These devices are used when the drug permeation rate is rapid
B)  The release of the drug is controlled
C)  Suitable for low therapeutic index
D)  The drug is contained in a powder from floating on liquid

Question 20

How many layer are seen in membrane-controlled system?

Accepted Answer

A)  3
B)  5
C)  4
D)  6

Exam 2: Transdermal Drug Delivery Systems TDDS and Formulations