Question 1

Low-risk ALL pediatric clinical trials require the WBC count to be less than:

Accepted Answer

A)   20  109/L
B)   50  109/L
C)   60  109/L
D)   75  109/L B

Question 2

The L3 classification of leukemia is defined by:

Accepted Answer

A)   Small homogeneous blasts
B)   Large vacuolated blasts
C)   Large heterogeneous blasts
D)   Predominance of prolymphocytes B

Question 3

Greater than __of bone marrow cells must be identified as lymphoblasts to meet the WHO definition of ALL.

Accepted Answer

A)   10%
B)   20%
C)   25%
D)   30% B

Question 4

Migration to extramedullary sites is a feature of which of the following leukemias?

Accepted Answer

A)   Acute progranulocytic leukemia
B)   Acute myelocytic leukemia
C)   Acute monocytic leukemia
D)   Acute lymphocytic leukemia

Question 5

Which CD marker best represents the earliest progenitor cells?

Accepted Answer

A)   CD11
B)   CD19
C)   CD34
D)   CD57

Question 6

Acute leukemic processes are marked by:

Accepted Answer

A)   Slow onset, slow progression, anemia
B)   Rapid onset anemia, thrombocytopenia
C)   Splenomegaly
D)   Less than 30% in the BM

Question 7

When performing flow cytometry, the technologist interpreted the flow pattern as exhibiting a high degree of CD14 and CD4 positive cells.The peripheral smear showed large multilobulated blast cells.This pattern is most representative of:

Accepted Answer

A)   ALL
B)   AMonoL
C)   AMML
D)   AML

Question 8

A patient with AML is likely to have a cytochemical stain panel that is positive for:

Accepted Answer

A)   Sodium fluoride with tartrate resistance
B)   MPO, SBB, specific esterase
C)   MP0, SBB, nonspecific esterase
D)   SBB and TdT

Question 9

According to current WHO classification criteria, acute leukemia is characterized by which of the following?

Accepted Answer

A)   Hypercellular bone marrow with greater than 20% blasts
B)   Hypercellular bone marrow with less than 20% blasts
C)   Hypocellular bone marrow with greater than 20% blasts
D)   Hypocellular bone marrow with less than 20% blasts

Question 10

A patient presents with generalized lymphadenopathy and a WBC of 100 F1F1F1S1F1F1F10 109/L.This hematologic picture would most likely be seen in:

Accepted Answer

A)   Chronic lymphocytic leukemia
B)   Acute lymphocytic leukemia
C)   Burkitt's lymphoma
D)   Hairy cell leukemia

Question 11

The t(15:17)(q22;q12) is associated with which of the following leukemias?

Accepted Answer

A)   Acute promyelocytic leukemia
B)   Acute myelomonocytic leukemia
C)   Acute lymphocytic leukemia
D)   Acute myelocytic leukemia

Question 12

-The structure at the end of the pointer is a(n):

Accepted Answer

A)   Auer rod
B)   Dohle body
C)   Engulfed bacteria
D)   None of the above

Question 13

Which of the following is characteristic of Auer rods?

Accepted Answer

A)   Composed of fused primary granules
B)   Predominantly seen in ALL
C)   Predominantly seen in HCL
D)   Composed of specific granules

Question 14

The monoclonal marker that is often positive in T-ALL is:

Accepted Answer

A)   CD1
B)   CD7
C)   CD10
D)   CD41

Question 15

___is the rarest form of the AMLs.

Accepted Answer

A)   M1
B)   M4
C)   M6
D)   M7

Question 16

The presence of CD2, CD5, and CD7 and the absence of CD10 is seen in:

Accepted Answer

A)   B lymphocytes
B)   T lymphocytes
C)   Myeloblasts
D)   Monoblasts

Question 17

______may arise as a blastic transformation in patients with CML.

Accepted Answer

A)   Acute basophilic leukemia
B)   Acute myelofibrosis
C)   Acute lymphocytic leukemia
D)   Erythroleukemia

Question 18

Pediatric patients with ALL have an overall complete remission rate of:

Accepted Answer

A)   50%
B)   65%
C)   75%
D)   95%

Question 19

-The cells pictured above are most consistent for:

Accepted Answer

A)   Acute myeloid leukemia
B)   Acute myelomonocytic leukemia
C)   Acute lymphoblastic leukemia
D)   Acute erythroid leukemia

Question 20

_is predominantly a disease of children.

Accepted Answer

A)   AML
B)   CML
C)   ALL
D)   CLL

Exam 11: Acute Leukemias

Low-risk ALL pediatric clinical trials require the WBC count to be less than:

The L3 classification of leukemia is defined by:

Greater than __of bone marrow cells must be identified as lymphoblasts to meet the WHO definition of ALL.

Migration to extramedullary sites is a feature of which of the following leukemias?

Which CD marker best represents the earliest progenitor cells?

Acute leukemic processes are marked by:

When performing flow cytometry, the technologist interpreted the flow pattern as exhibiting a high degree of CD14 and CD4 positive cells.The peripheral smear showed large multilobulated blast cells.This pattern is most representative of:

A patient with AML is likely to have a cytochemical stain panel that is positive for:

According to current WHO classification criteria, acute leukemia is characterized by which of the following?

A patient presents with generalized lymphadenopathy and a WBC of 100  10⁹/L.This hematologic picture would most likely be seen in:

The t(15:17) (q22;q12) is associated with which of the following leukemias?

-The structure at the end of the pointer is a(n) :

Which of the following is characteristic of Auer rods?

The monoclonal marker that is often positive in T-ALL is:

___is the rarest form of the AMLs.

The presence of CD2, CD5, and CD7 and the absence of CD10 is seen in:

______may arise as a blastic transformation in patients with CML.

Pediatric patients with ALL have an overall complete remission rate of:

-The cells pictured above are most consistent for:

_is predominantly a disease of children.

Exam 11: Acute Leukemias

Low-risk ALL pediatric clinical trials require the WBC count to be less than:

The L3 classification of leukemia is defined by:

Greater than __of bone marrow cells must be identified as lymphoblasts to meet the WHO definition of ALL.

Migration to extramedullary sites is a feature of which of the following leukemias?

Which CD marker best represents the earliest progenitor cells?

Acute leukemic processes are marked by:

When performing flow cytometry, the technologist interpreted the flow pattern as exhibiting a high degree of CD14 and CD4 positive cells.The peripheral smear showed large multilobulated blast cells.This pattern is most representative of:

A patient with AML is likely to have a cytochemical stain panel that is positive for:

According to current WHO classification criteria, acute leukemia is characterized by which of the following?

A patient presents with generalized lymphadenopathy and a WBC of 100  109/L.This hematologic picture would most likely be seen in:

The t(15:17) (q22;q12) is associated with which of the following leukemias?

-The structure at the end of the pointer is a(n) :

Which of the following is characteristic of Auer rods?

The monoclonal marker that is often positive in T-ALL is:

___is the rarest form of the AMLs.

The presence of CD2, CD5, and CD7 and the absence of CD10 is seen in:

______may arise as a blastic transformation in patients with CML.

Pediatric patients with ALL have an overall complete remission rate of:

-The cells pictured above are most consistent for:

_is predominantly a disease of children.

A patient presents with generalized lymphadenopathy and a WBC of 100  10⁹/L.This hematologic picture would most likely be seen in: