Question 1

What is the name of the gene that makes the RNA thought to be responsible for the inactivation if the X chromosome?

Accepted Answer

A) INAC 
B) XIST 
C) 1STX 
D) IRS 
E) XCHR

Question 2

What level of control of gene expression is defined as regulating whether or not a particular mRNA is actually used in protein synthesis and,if so,how long and for how long a period of time?

Accepted Answer

A) transcriptional-level controls 
B) processing-level controls 
C) translational-level controls 
D) replication-level controls 
E) denaturation-level controls

Question 3

Covalent linkage to what small,highly-conserved protein marks proteins for destruction?

Accepted Answer

A) chaperonin 
B) actin 
C) ubiquitin 
D) cyclin 
E) dystrophin

Question 4

What site on a bacterial operon segment of a chromosome is adjacent to or overlaps with a promoter?

Accepted Answer

A) operator 
B) terminator 
C) activator 
D) repressor 
E) structural genes

Question 5

The localization of mRNAs is mediated by specific proteins that recognize mRNA localization sequences on the mRNAs.What name has been given to these sequences?

Accepted Answer

A) mRNA localizers 
B) localicodes 
C) zip-codes 
D) ziptrons 
E) zaptronics

Question 6

When DNA-binding proteins are removed from immunoprecipitated DNA sequences and the DNA fragments precipitated by the antibody are subsequently sequenced directly to determine the genomic sites bound,the technique is called __________.

Accepted Answer

A) Hip-chip 
B) ChIP-chip 
C) ChIP-seq 
D) chromatin immunoprecipitation 
E) ChIP

Question 7

The thin filamentous meshwork within the nucleus that is bound by integral membrane proteins of the inner surface of the nuclear envelope in animal cells is called the _________.

Accepted Answer

A) basement lamina 
B) basal lamina 
C) nuclear lamina 
D) nucleon 
E) nuclear limulus

Question 8

When present,the TATA,CAAT and GC boxes are typically found within 100 - 150 bp upstream from the transcription start site.Due to their closeness to the start of gene,they are often called ______.

Accepted Answer

A) distal promoter elements 
B) proximal promoter elements 
C) central promoter sites 
D) primary promoter elements 
E) primary promoter sites

Question 9

A complex of exonucleases that degrades mRNAs is called the ______.

Accepted Answer

A) endosome 
B) execrosome 
C) exosome 
D) enterosome 
E) edusome

Question 10

What domain of a transcription factor is responsible for recognizing and associating with specific DNA base pair sequences?

Accepted Answer

A) the DNA-binding domain 
B) the activation domain 
C) the repression domain 
D) the DNA-unwinding domain 
E) the DNA-derepression domain

Question 11

What is thought to maintain X chromosome inactivation?

Accepted Answer

A) repressive histone modifications 
B) RNA inactivation 
C) DNA methylation 
D) localized DNA denaturation 
E) both repressive histone modifications and DNA methylation

Question 12

Deadenylation,decapping and 5' -> 3' degradation occur within small,transient cytoplasmic granules called _________.

Accepted Answer

A) P-granules 
B) P-coats 
C) decappers 
D) P-bodies 
E) degradators

Question 13

Why does the activation of a protein kinase that acts on initiation factor eIF2 block protein synthesis?

Accepted Answer

A) Phosphorylated eIF2 denatures. 
B) Phosphorylated eIF2 cannot exchange its GDP for GTP,which is required for eIF2 to participate in another round of translation initiation. 
C) Phosphorylated eIF2 cannot exchange its GTP for GDP,which is required for eIF2 to participate in another round of translation initiation. 
D) Phosphorylated eIF2 is hyperactivated,blocking further translation. 
E) Dephosphorylated eIF2 cannot exchange its GDP for GTP,which is required for eIF2 to participate in another round of translation initiation.

Question 14

What experimental evidence suggests that the N-terminal tails of histones participate in the formation of higher-order chromatin structure?

Accepted Answer

A) The tails cause histones to denature. 
B) The tails when acetylated cause the dissolution of the 30-nm fibers. 
C) Chromatin fibers prepared with H4 histones lacking their tails cannot fold into higher-order fibers. 
D) Chromatin fibers prepared with H4 histones possessing longer tails cannot fold into higher-order fibers. 
E) Chromatin fibers lacking tails are shorter.

Question 15

Why might localizing mRNAs in the oocyte be more efficient than localizing the proteins they encode?

Accepted Answer

A) Messenger RNAs are easier to move than proteins. 
B) Each mRNA can be translated into a limited number of proteins. 
C) Each mRNA can be translated into a large number of proteins. 
D) Messenger RNAs are easier to immobilize than proteins. 
E) Localizing proteins would denature them.

Question 16

$\beta$-galactosidase is encoded by the ___________.

Accepted Answer

A) y gene of the lac operon 
B) z gene of the lac operon 
C) a gene of the lac operon 
D) y gene of the trp operon 
E) z gene of the trp operon

Question 17

Which transcription factor helps to activate genes needed for cell division?

Accepted Answer

A) Egr 
B) Csn 
C) GATA 
D) GATO 
E) espn

Question 18

The DNA loops of 80 - 100 nm fibers begin and end with _______.

Accepted Answer

A) AT-rich sequences 
B) GC-rich sequences 
C) GT-rich sequences 
D) poly(
A) chains 
E) single-stranded portions

Question 19

Each transcription factor usually has at least two domains that mediate different aspects of their function.What are they?

Accepted Answer

A) the DNA-binding domain and the activation domain 
B) the activation domain and the repression domain 
C) the DNA-binding domain and the repression domain 
D) the RNA-binding domain and the activation domain 
E) the RNA-binding domain and the repression domain

Question 20

The inactive mRNAs that are stored in an egg prior to fertilization typically have ________.

Accepted Answer

A) lenghtened 5' UTRs 
B) lenghtened poly(
A) tails 
C) shortened poly(
A) tails 
D) many lipids associated with them 
E) shortened 5' UTRs

Exam 12: Control of Gene Expression

What is the name of the gene that makes the RNA thought to be responsible for the inactivation if the X chromosome?

What level of control of gene expression is defined as regulating whether or not a particular mRNA is actually used in protein synthesis and,if so,how long and for how long a period of time?

Covalent linkage to what small,highly-conserved protein marks proteins for destruction?

What site on a bacterial operon segment of a chromosome is adjacent to or overlaps with a promoter?

The localization of mRNAs is mediated by specific proteins that recognize mRNA localization sequences on the mRNAs.What name has been given to these sequences?

When DNA-binding proteins are removed from immunoprecipitated DNA sequences and the DNA fragments precipitated by the antibody are subsequently sequenced directly to determine the genomic sites bound,the technique is called __________.

The thin filamentous meshwork within the nucleus that is bound by integral membrane proteins of the inner surface of the nuclear envelope in animal cells is called the _________.

When present,the TATA,CAAT and GC boxes are typically found within 100 - 150 bp upstream from the transcription start site.Due to their closeness to the start of gene,they are often called ______.

A complex of exonucleases that degrades mRNAs is called the ______.

What domain of a transcription factor is responsible for recognizing and associating with specific DNA base pair sequences?

What is thought to maintain X chromosome inactivation?

Deadenylation,decapping and 5' -> 3' degradation occur within small,transient cytoplasmic granules called _________.

Why does the activation of a protein kinase that acts on initiation factor eIF2 block protein synthesis?

What experimental evidence suggests that the N-terminal tails of histones participate in the formation of higher-order chromatin structure?

Why might localizing mRNAs in the oocyte be more efficient than localizing the proteins they encode?

$\beta$ -galactosidase is encoded by the ___________.

Which transcription factor helps to activate genes needed for cell division?

The DNA loops of 80 - 100 nm fibers begin and end with _______.

Each transcription factor usually has at least two domains that mediate different aspects of their function.What are they?

The inactive mRNAs that are stored in an egg prior to fertilization typically have ________.

Exam 12: Control of Gene Expression

What is the name of the gene that makes the RNA thought to be responsible for the inactivation if the X chromosome?

What level of control of gene expression is defined as regulating whether or not a particular mRNA is actually used in protein synthesis and,if so,how long and for how long a period of time?

Covalent linkage to what small,highly-conserved protein marks proteins for destruction?

What site on a bacterial operon segment of a chromosome is adjacent to or overlaps with a promoter?

The localization of mRNAs is mediated by specific proteins that recognize mRNA localization sequences on the mRNAs.What name has been given to these sequences?

When DNA-binding proteins are removed from immunoprecipitated DNA sequences and the DNA fragments precipitated by the antibody are subsequently sequenced directly to determine the genomic sites bound,the technique is called __________.

The thin filamentous meshwork within the nucleus that is bound by integral membrane proteins of the inner surface of the nuclear envelope in animal cells is called the _________.

When present,the TATA,CAAT and GC boxes are typically found within 100 - 150 bp upstream from the transcription start site.Due to their closeness to the start of gene,they are often called ______.

A complex of exonucleases that degrades mRNAs is called the ______.

What domain of a transcription factor is responsible for recognizing and associating with specific DNA base pair sequences?

What is thought to maintain X chromosome inactivation?

Deadenylation,decapping and 5' -> 3' degradation occur within small,transient cytoplasmic granules called _________.

Why does the activation of a protein kinase that acts on initiation factor eIF2 block protein synthesis?

What experimental evidence suggests that the N-terminal tails of histones participate in the formation of higher-order chromatin structure?

Why might localizing mRNAs in the oocyte be more efficient than localizing the proteins they encode?

β\betaβ -galactosidase is encoded by the ___________.

Which transcription factor helps to activate genes needed for cell division?

The DNA loops of 80 - 100 nm fibers begin and end with _______.

Each transcription factor usually has at least two domains that mediate different aspects of their function.What are they?

The inactive mRNAs that are stored in an egg prior to fertilization typically have ________.

$\beta$ -galactosidase is encoded by the ___________.