Which Statement About Protein-Ligand Binding Is CORRECT

Multiple Choice

Which statement about protein-ligand binding is CORRECT?

A) The K_a is equal to the concentration of ligand when all of the binding sites are occupied.
B) The K_a is independent of such conditions as salt concentration and pH.
C) The larger the K_a (association constant) , the weaker the affinity.
D) The larger the K_a, the faster is the binding.
E) The larger the K_a, the smaller the K_d (dissociation constant) .