Deck 24: Drugs Used to Manage Pain

Question 1

Which of the following is a prodrug that is converted by the liver into morphine?

A)codeine
B)fentanyl
C)meperidine
D)buprenorphine

Answer 1

codeine

Question 2

Capsaicin cream is made from:

A)Tomato paste.
B)Citrus juice.
C)Hot peppers.
D)Mushrooms.

Answer 2

Hot peppers.

Question 3

For potentially debilitating pain for which the exact cause may not be known,how long must it last to be considered chronic pain?

A)1 month
B)2 months
C)3 months
D)4 months

Answer 3

3 months

Question 4

Which of the following is recommended for the treatment of constipation due to opioids?

A)sennosides (Senakot)
B)Bulking agents
C)Fiber laxatives
D)Plain fiber

Question 5

Ziconotide must be administered via which of the following routes?

A)Intrathecally
B)Orally
C)Transdermal
D)Intramuscular

Question 6

Which of the following drugs has antagonistic effects at delta and kappa sites?

A)naloxone
B)buprenorphine
C)fentanyl
D)codeine

Question 7

Morphine (Avinza)contains fumaric acid and may cause which of the following conditions?

A)Liver toxicity
B)Ototoxicity
C)Nephrotoxicity
D)Neurotoxicity

Question 8

Which of the following is a Mu antagonist?

A)buprenorphine
B)naloxone (Narcan)
C)methadone
D)morphine

Question 9

What is the definition of allodynia?

A)Pain out of proportion to the injury
B)Pain response produced from non-noxious stimuli
C)Decreased sensitivity to pain
D)Lack of pain response

Question 10

Naltrexone is how much more potent than naloxone,and thus used for rapid detox?

A)1 to 2 times
B)2 to 3 times
C)3 to 5 times
D)4 to 6 times

Question 11

Pruritus due to opioids can be treated with which of the following drugs?

A)vancomycin
B)cetirizine (Zyrtec)
C)prochlorperazine
D)metoclopramide

Question 12

Acute pain commonly causes which of the following conditions?

A)Hypertension
B)Bradycardia
C)Meiosis
D)Dry mouth

Question 13

Which antagonist/agonist opioid analgesic is available as a nasal spray and an IV injection?

A)butorphanol (Stadol)
B)pentazocine (Talwin)
C)nalbuphine (Nubain)
D)buprenorphine (Buprenex)

Question 14

Tramadol is metabolized in the:

A)Large intestine.
B)Liver.
C)Stomach.
D)Small intestine.

Question 15

Hydromorphone is usually metabolized by which of the following:

A)CYPP450,1A3,2B7.
B)P4503A4
C)P4503C4
D)CPC40

Question 16

Which of the following drugs can cause QT interval prolongation?

A)morphine
B)hydromorphone
C)buprenorphine
D)codeine

Question 17

Which of the following drugs can be used for treatment of overdose with opioids?

A)propoxyphene
B)meperidine
C)diphenhydramine
D)naloxone (Narcan)

Question 18

What pregnancy risk category is methylnaltrexone (Relistor)?

A)Category A
B)Category B
C)Category C
D)Category D

Question 19

Which of the following is a synthetic opioid agent?

A)codeine
B)hydrocodone
C)fentanyl
D)butorphanol

Question 20

Which of the following drugs can be used to treat bone pain?

A)octreotide
B)hyoscyamine
C)scopolamine
D)bisphosphonates

Question 21

Which of the following describes the mechanism of action of NSAIDs?

A)Inhibition of the cyclooxygenase enzyme
B)Activation of the cyclooxygenase enzyme
C)Activation of phospholipids
D)Activation of lipoxygenase

Question 22

What is the half-life of tapentadol (Nucynta)?

A)12 hours
B)24 hours
C)36 hours
D)48 hours

Question 23

99% of NSAIDS are excreted via:

A)Liver.
B)Feces.
C)Saliva.
D)Urine.

Question 24

Acetaminophen has which of the following properties?

A)Antiplatelet
B)Anti-inflammatory
C)Antirheumatologic agent
D)Antipyretic

Question 25

NSAIDs are metabolized in the:

A)Duodenum.
B)Stomach.
C)Liver.
D)Large intestine.

Question 26

What is the maximum amount of acetaminophen that can be given to an adult (age older than 12 years)in one day?

A)1 gram
B)2 grams
C)3 grams
D)4 grams

Question 27

Caregivers should be warned to avoid giving aspirin to a teenager with which condition?

A)Sinusitis
B)Bronchitis
C)Influenza
D)Ankle sprain

Question 28

Aspirin is secreted via:

A)Feces.
B)Sweat.
C)Urine.
D)Liver.

Question 29

Acetaminophen's plasma half-life is:

A)1 to 2 hours.
B)1 to 3 hours.
C)1 to 4 hours.
D)1 to 5 hours.

Question 30

Which of the following drugs is a COX-2 inhibitors

A)aspirin
B)celecoxib
C)ibuprofen
D)naproxen

Question 31

NSAIDs should not be given late in pregnancy because they may cause which of the following?

A)Preterm labor
B)Low-birth-weight baby
C)Deep vein thrombosis
D)Premature closure of the ductus arteriosus

Question 32

For how many days does the inhibitory effect of aspirin on platelet aggregation last until new platelets are formed?

A)2 days
B)4 days
C)6 days
D)8 days

Question 33

What chemical class of medication is indomethacin (Indocin)?

A)Fenamate
B)Phenylacetic acid
C)Propionic acid
D)Indoleacetic acid

Question 34

Where is COX-1 found?

A)Brain
B)Heart
C)Lung
D)Gastrointestinal (GI)mucosa

Question 35

The effects of which of the following drugs may be enhanced in the presence of acetaminophen?

A)warfarin
B)carbamazepine
C)isoniazid
D)rifampin

Question 36

What is the typical dose for ibuprofen?

A)500 mg initially followed by 250 mg every 6 to 8 hours
B)400 to 800 mg three to four times a day
C)1,200 mg once a day
D)200 mg every 12 hours

Question 37

Acetaminophen is considered to be in which pregnancy risk category?

A)Category A
B)Category B
C)Category C
D)Category D

Question 38

Which of the following situations can occur in patients experiencing poisoning by aspirin tablets?

A)Respiratory acidosis and metabolic acidosis
B)Respiratory alkalosis and metabolic alkalosis
C)Respiratory acidosis and metabolic alkalosis
D)Metabolic acidosis and respiratory alkalosis

Question 39

High doses of aspirin can cause which of the following?

A)Constipation
B)Tinnitus
C)Deep vein thrombosis
D)Fatigue

Question 40

Which of the following is effective if given less than 24 hours after ingestion of an acetaminophen overdose?

A)naloxone (Narcan)
B)N-acetylcysteine (Mucomyst,Mucosol)
C)deferoxamine (Desferal)
D)syrup of ipecac