Deck 19: Introduction to Thrombosis and Anticoagulant Therapy

Question 1

Heparin therapy is monitored best by performing routine:

A)PT/INRs
B)Anti-factor Xa
C)Fibrinogen levels
D)Bleeding time tests

Answer 1

B

Question 2

All of the following statements describe factor V Leiden except:

A)It is a cause of activated protein C resistance.
B)It is associated with thrombocytopenia.
C)It is associated with increased risk of thrombosis.
D)Is an inherited disorder.

Answer 2

B

Question 3

Antithrombin inhibits all of the following factors except:

A)IIa
B)VIIa
C)IXa
D)XIa

Answer 3

B

Question 4

The international normalized ratio (INR) is useful in:

A)The detection of coagulation factor deficiencies
B)Monitoring heparin therapy
C)The detection of inhibitors
D)Monitoring Coumadin therapy

Question 5

All of the following can cause thrombosis except:

A)Low platelet count
B)Activation of coagulation systems
C)Vascular injury
D)Deficiencies of coagulation inhibitors

Question 6

Which of the following PT results would most likely be seen in a patient who is on Coumadin and is stable?

A)Approximately 26 seconds
B)Approximately 13 seconds
C)Approximately 40 seconds
D)Approximately 60 seconds

Question 7

Heparin-induced thrombocytopenia (HIT) usually:

A)Occurs as a result of protein C deficiency
B)Will show an increase in platelets
C)Occurs 5 to 14 days after heparin therapy
D)Occurs only in males

Question 8

Protein C is activated by which of the following?

A)Heparin cofactor II
B)Factor VIIIa
C)Antithrombin
D)Protein S

Question 9

All of the following statements are true regarding Coumadin except:

A)It is a vitamin K antagonist.
B)It needs antithrombin as a cofactor.
C)PT is used to monitor its dosage.
D)It is not recommended for pregnant and lactating women.

Question 10

Factor Xa inhibitors are monitored using which assay?

A)APTT
B)PT
C)anti-factor Xa assay
D)platelet count

Question 11

Heparin:

A)Inhibits PF3
B)Inhibits thrombin
C)Degrades antithrombin
D)Forms a complex with protein C

Question 12

The target therapeutic range for an INR in patients with thromboembolic disease is:

A)1 to 2
B)1.5 to 2.5
C)2 to 3
D)2 to 2.5

Question 13

Which test should be ordered as a baseline before started heparin therapy on a patient?

A)PT
B)Platelet count
C)APTT
D)Fibrinogen

Question 14

What is the term for the condition that predisposes patients to thrombosis?

A)Thrombopenia
B)Thrombophilia
C)Thrombocytosis
D)Anemia

Question 15

Arterial thrombosis is associated with:

A)Antithrombin deficiency
B)Protein S deficiency
C)Protein C deficiency
D)Both protein S and C deficiencies

Question 16

All of the following are naturally occurring thrombin inhibitors except:

A)AT
B)Prothrombin cofactor II
C)Protein C
D)Plasmin

Question 17

The most common tests used to detect lupus anticoagulants include all of the following except:

A)aPTT
B)Kaolin clotting time
C)PT/INR
D)Dilute Russell viper venom test

Question 18

Drug alternatives for patients with heparin-induced thrombocytopenia include:

A)Danaparoid
B)Warfarin
C)Streptokinase
D)Aspirin

Question 19

Coumadin acts in such a way that it:

A)Alters the synthesis of vitamin K-dependent factors
B)Reduces the circulating level of factors III and V
C)Reduces the circulating level of factor I
D)Cleaves carboxyreductase to generate glutamic acid

Question 20

The lupus anticoagulant is directed against:

A)Factor VIII
B)Factor X
C)Factor IX
D)Phospholipids