Deck 13: Hematopoeitc Malignancies

Question 1

Which of the following usually has skeletal lesions?
a.MGUS
b.myeloma
c.macroglobulinemia
d.B and C
e.all of the above

Answer 1

myeloma

Question 2

Beta-2 microglobulin is part of the class I molecule and is elevated and a tumor marker for
a.multiple myeloma
b.chronic lymphocytic leukemia
c.some lymphomas
d.all of the above
e.none of the above

Answer 2

all of the above

Question 3

Bence-Jones proteins are in the urine of patients with
a.testicular cancer
b.lung cancer
c.myeloma
d.pancreatic cancer

Answer 3

myeloma

Question 4

Electroendosmosis can cause
a.albumin to move toward the anode
b.heat to be generated during electrophoresis
c.proteins to be denatured during electrophoresis
d.IgG to be swept toward the cathode

Question 5

Plasma cell dyscrasias include
a.multiple myeloma
b.macroglobulinemia
c.monoclonal gammopathy of undetermined significance
d.A and B
e.all of the above

Question 6

The most common isotypes for multiple myeloma are
a.IgG and IgM
b.IgM and IgA
c.IgG, IgA, and IgM
d.IgG and IgA

Question 7

The blood level of which of the following mineral ions increases in multiple myeloma?
a.Mg
b.Mn
c.Fe
d.Ca

Question 8

Rouleaux are
a.stacks of red blood cells resulting from serum viscosity changes that are seen in macroglobulinemia
b.white cheeks resulting from the color loss in skin caused by the anemia of myeloma
c.light chains that precipitate causing amyloidosis
d.none of the above

Question 9

Electroendosmosis can cause
a.albumin to move toward the anode
b.heat to be generated during electrophoresis
c.proteins to be denatured during electrophoresis
d.IgG to be swept toward the cathode

Question 10

The differences between leukemia and lymphoma include
a.Leukemia arises in the bone marrow, but lymphoma arises from mature lymphoid cells in the lymphatic organs.
b.Leukemia is always curable, but only Hodgkin's lymphoma is curable.
c.Leukemia is an undifferentiated cell, but lymphoma is always derived from mature T cells.
d.Leukemia is from B cells, but lymphoma is from T cells.

Question 11

Rituximab, Bexxar, and Zevalin are
a.antibodies to CD 19 used to treat Hodgkin's lymphoma
b.antibodies to surface immunoglobulins used to treat non-Hodgkin's lymphoma
c.antibodies to CD20 used to treat non-Hodgkin's lymphoma
d.antibodies to CD52 used to treat myelomas

Question 12

A patient with MGUS
a.has a prognosis of 50% survival at 3 years
b.will be fine after a bone marrow transplant
c.needs only passive transfer of immunoglobulin
d.will be relieved about the diagnosis

Question 13

Which of the following is correct for immunofixation electrophoresis?

A)After electrophoresis, a trough is cut parallel to the direction of the current and is filled with antibody.
B)After electrophoresis, a trough is cut perpendicular to the direction of the current and is filled with antibody.
C)After electrophoresis, antibody is placed directly over the gel.
D)Before electrophoresis, antibody is placed in the gel.

Question 14

To diagnose myeloma,
a.serum protein electrophoresis is followed by flow cytometry, which is followed by immunofixation electrophoresis
b.serum protein electrophoresis is followed by flow cytometry, which is followed by immunoglobulin quantitation by nephelometry
c.serum protein electrophoresis is followed by immunofixation electrophoresis and immunoglobulin quantitation
d.flow cytometry is followed by immunofixation electrophoresis

Question 15

Sometimes enlarged lymph nodes may be the result of non-Hodgkin's lymphoma but more often are the result of infection. Which of the following is the primary way to rule out that infection?
a.A biopsy is done immediately and is looked at microscopically.
b.Antibiotics are given to see whether the lymph node has decreased in size.
c.Measure the size to determine whether the lymph node is larger than a certain size; if so, it is a tumor.
d.Measure the patient's temperature; if it is elevated, the swelling is due to an infection.

Question 16

Which of the following is correct for serum protein electrophoresis?
a.After electrophoresis, the gel is washed in buffer, then stained with a stain which will stain, fix and precipitate proteins
b.After electrophoresis, the gel is stained with a stain which will stain, fix and precipitate proteins
c.After electrophoresis, antibody is place directly over the gel
d.Before electrophoresis, antibody is placed in the gel

Question 17

Hodgkin's lymphoma has
a.cells that look like an owl's eye because of the bilobed nucleus
b.a low 5-year survival rate
c.bone marrow transplantation as the first line of therapy
d.A and C

Question 18

The most common isotype(s) for macroglobulinemia is(are)
a.IgA
b.IgM
c.IgG, IgA, and IgM
d.IgG and IgA

Question 19

Leukemias and lymphomas are diagnosed by
a.flow cytometry
b.serum protein electrophoresis followed by immunofixation electrophoresis
c.turbidometry followed by flow cytometry
d.A and B

Question 20

To determine immunoglobulin concentration,
a.serum protein electrophoresis is followed by densitometry to determine percentage of the protein and this is combined with the total serum protein concentration to yield concentration of the tumor produced immunoglobulin.
b.serum protein electrophoresis is followed by densitometry to yield concentration of the tumor produced immunoglobulin.
c.serum protein electrophoresis is followed by immunofixation electrophoresis to yield the concentration of the tumor produced immunoglobulin
d.flow cytometry is followed by immunofixation electrophoresis

Question 21

A leukemia of mature lymphocytes found in people over 50 is most likely to be
a.chronic lymphocytic leukemia
b.acute lymphocytic leukemia
c.chronic myeloid leukemia
d.acute myeloid leukemia

Question 22

Reynaud's phenomena involves
a.autoimmunity to the thyroid gland
b.pain in the hands and feet because of cryoglobulins
c.a type of lymphoma
d.swollen joints

Question 23

Which of the following is true for both adult and childhood versions of leukemia?
a.have the same prognosis
b.require the same treatment modalities
c.may be very different diseases
d.A and B

Question 24

Which of the following is not a clinical symptom of multiple myeloma?
a.increased infection rate subsequent to the myeloma
b.increased bleeding subsequent to the myeloma
c.increased bone fractures subsequent to the myeloma
d.increased rate of autoimmune diseases subsequent to the myeloma

Question 25

Risk factors for plasma cell dyscrasias include
a.age younger than 60
b.immunodeficiency diseases
c.having mumps
d.drinking too much water