Deck 12: The Major Histocompatibility Complex

Question 1

Matching
Match each of the definitions in questions with the MHC nomenclature (A-F).
Mouse major histocompatibility complex

A)HLA-α1
, -B7, -Cw4, -DPw5, -DQw10, -DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd

Answer 1

H-2

Question 2

For each region of a class I MHC molecule listed in questions , match the lettered label (A-D) from the diagram shown below.

Peptide-binding groove

Answer 2

C
The peptide-binding groove of class I MHC molecules is formed by approximately 90 amino acids of the N-terminal a heavy chain, which includes the α1 and α2 domains This groove is composed of a floor of β-pleated sheet and two parallel strands of a helix.

Question 3

For each region of a class I MHC molecule listed in questions , match the lettered label (A-D) from the diagram shown below.

β2-Microglobulin

Answer 3

D
β2-Microglobulin is a separate polypeptide containing a single Ig domain, which is noncovalently associated with the extracellular region of the a heavy chain of class I MHC molecules.

Question 4

Matching
Match each of the definitions in questions with the MHC nomenclature (A-F).
Inbred mouse strain MHC haplotype

A)HLA-α1
, -B7, -Cw4, -DPw5, -DQw10, -DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd

Question 5

Matching
Match each of the definitions in questions with the MHC nomenclature (A-F).
Human MHC haplotype

A)HLA-α1
, -B7, -Cw4, -DPw5, -DQw10, -DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd

Question 6

For each region of a class I MHC molecule listed in questions , match the lettered label (A-D) from the diagram shown below.

Polymorphic region

Question 7

Matching
Match each of the definitions in questions with the MHC nomenclature (A-F).
Human class I MHC allele

A)HLA-α1
, -B7, -Cw4, -DPw5, -DQw10, -DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd

Question 8

Matching
Match each of the definitions in questions with the MHC nomenclature (A-F).
Mouse class II MHC allele

A)HLA-α1
, -B7, -Cw4, -DPw5, -DQw10, -DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd

Question 9

For each region of a class I MHC molecule listed in questions , match the lettered label (A-D) from the diagram shown below.

CD8-binding site