Deck 18: Antigen Presentation for Cell-Mediated Response

Question 1

Which of the following is an example of an immune response following cross-priming?
I. An NK cell killing a tumor cell.
II. A CD8 cell killing a tumor cell.
III. A macrophage ingesting a tumor cell.

A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Answer 1

III only

Question 2

MHC class I molecules present antigen to:

A) NK cells
B) CD8 T cells
C) CD4 Th1 cells
D) CD4 Th2 cells

Answer 2

CD8 T cells

Question 3

As antigen is processed prior to loading onto MHC class I molecules, the antigens are degraded into smaller fragments by the:

A) Proteasome
B) Golgi apparatus
C) Phagolysosome
D) Endoplasmic reticulum (ER)

Answer 3

Proteasome

Question 4

What is the purpose of b₂-microglobulin associated with MHC class I molecules?

A) Stabilization
B) Interacts with T cell
C) Anchors to membrane
D) Scaffolding molecule between TAP and MHC class I molecule

Question 5

Which of the following is most likely to generate a CD8 T cell response?

A) Tapeworm infection
B) Influenza virus infection
C) Fungal infection causing athlete's foot
D) Group A Streptococcus infection (Strep throat)