Deck 26: Treatment of Gastroesophageal Reflux Disease, Laryngopharyngeal Reflux, and Peptic Ulcer Disease

Question 1

Why might nonsteroidal anti-inflammatory drugs (NSAIDs)worsen GERD?

A)Increase gastric acids
B)Decrease mucosal lining
C)Impair peristalsis
D)Decrease natural reflux barriers

Answer 1

Decrease mucosal lining

Question 2

Taking a PPI on an empty stomach is recommended because _____.

A)it will have time to work by the time a meal is eaten
B)it is easily broken down and destroyed by acid in the stomach
C)absorption of the drug is inhibited by food
D)taking it with food decreases the likelihood of the drug causing side effects

Answer 2

it is easily broken down and destroyed by acid in the stomach

Question 3

How would taking an H₂ receptor antagonist help prevent peptic ulcers?

A)Increases the production of the digestive enzyme pepsin,increasing its stomach protection abilities
B)Eliminates production of the digestive enzyme pepsin in the stomach,decreasing its exposure
C)Decreases acidity in stomach,decreasing chronic exposure to the digestive enzyme pepsin
D)Binds to the digestive enzyme pepsin in the stomach,decreasing its availability

Answer 3

Decreases acidity in stomach,decreasing chronic exposure to the digestive enzyme pepsin

Question 4

Which of the following would the pharmacist not counsel a patient with GERD to avoid?

A)Smoking
B)Alcohol
C)Exercise
D)Diet

Question 5

Which of the following is available as an over-the-counter (OTC)proton pump inhibitor?

A)Lansoprazole
B)Pantoprazole
C)Esomeprazole
D)Rabeprazole

Question 6

One of the treatment goals for GERD,LPR,and PUD is aimed at _____.

A)reducing pepsin
B)lessening mucus secretion
C)eliminating stomach acid
D)decreasing prostaglandins

Question 7

Which of the following would not be classified as a H₂ receptor antagonist?

A)Cimetidine
B)Ranitidine
C)Famotidine
D)Amantadine

Question 8

Which of the following H₂ receptor antagonists can cause the development of gynecomastia in men and inhibit several cytochrome P450 metabolic enzymes?

A)Cimetidine
B)Famotidine
C)Nizatidine
D)Ranitidine

Question 9

Which of the following warning labels should be placed on a PPI prescription?

A)May decrease libido.
B)May cause depression.
C)May cause breast tenderness.
D)May cause nausea.

Question 10

Which condition may increase the risk of developing asthma?

A)COPS
B)GERD
C)PUD
D)LPR

Question 11

Which of the following drugs is used to treat GERD,LPR,and PUD?

A)Desloratadine
B)Nizatidine
C)Diphenhydramine
D)Cholestyramine

Question 12

How do salicylates increase the risk of PUD?

A)Salicylates contain an enzyme that H.pylori feed on,increasing bacteria in the gastrointestinal (GI)tract.
B)Salicylates block prostaglandins from forming,reducing the protective mucosal lining of the GI tract.
C)Salicylates increase production of histamine in the stomach,increasing acid in the GI tract.
D)Salicylates interfere with the formation of acid,reducing enzymes in the GI tract.

Question 13

Which of the following is a proton pump inhibitor?

A)Fluconazole
B)Metronidazole
C)Pantoprazole
D)Miconazole

Question 14

What is the main indication of misoprostol?

A)Prevention of NSAID-induced peptic ulcers
B)Maintenance of NSAID-induced peptic ulcers
C)Prevention of duodenal ulcers
D)Maintenance of duodenal ulcers

Question 15

Which of the following is not characteristic of an ulcer?

A)Open sore
B)Open wound
C)Can occur anywhere in the body
D)Limited to the digestive system

Question 16

All of the following medications can cause an ulcer to develop except _____.

A)acetylsalicylic acid
B)diflunisal
C)misoprostol
D)prednisone

Question 17

An example of a mucosal protectant that decreases the susceptibility of epithelial cells that line the stomach and small intestine to damage by gastric acids,pepsin,and H.pylori is _____.

A)pantoprazole
B)misoprostol
C)metoclopramide
D)rabeprazole

Question 18

Which of the following best explains why LPR occurs?

A)Ingestion of H.pylori bacteria eats away at esophagus lining.
B)LPR is passed down genetically.
C)An immature digestive system causes reflux and delayed gastric emptying.
D)The ability of natural reflux barriers to work properly becomes damaged.

Question 19

Why is it important to include the warning label "Avoid alcohol" on a prescription for GERD and PUD?

A)Alcohol stimulates stomach acid production,irritating an existing ulcer.
B)Alcohol is a gastric irritant.
C)Alcohol interferes with the elimination of drugs used for GERD and PUD.
D)Alcohol inhibits protective enzymes from forming,causing additional ulcers.

Question 20

Which of the following warning labels should be placed on a H₂ receptor antagonist?

A)May cause dizziness or drowsiness.
B)May cause vomiting.
C)May cause jaundice.
D)May cause dark yellow or brown urine.

Question 21

Which of the following warning labels should be placed on a prescription for misoprostol?

A)Take on an empty stomach.
B)Avoid pregnancy.
C)May cause discoloration of urine or feces.
D)Store in refrigerator.

Question 22

Which of the following explains how sucralfate works?

A)It stimulates production of bicarbonate in the stomach.
B)It increases regeneration of parietal cells in the stomach.
C)It forms a protective barrier over an ulcer to protect it from gastric acid.
D)It stimulates the production of gastric acids in the stomach to form a barrier.

Question 23

What is the main indication of sucralfate?

A)Prevention of NSAID-induced peptic ulcers
B)Maintenance of NSAID-induced peptic ulcers
C)Prevention of duodenal ulcers
D)Maintenance of duodenal ulcers

Question 24

MATCHING
Match each of the following trade names with its corresponding generic name.
a.Omeprazole
b.Sucralfate
c.Nizatidine
d.Metoclopramide
e.Calcium carbonate
Carafate

Question 25

Which of the following must be dispensed in the manufacturer's original container?

A)Sucralfate
B)Misoprostol
C)Omeprazole
D)Metoclopramide

Question 26

For which of the following GI disease states are antimicrobials prescribed?

A)GERD
B)LPR
C)PUD
D)PID

Question 27

MATCHING
Match each of the following trade names with its corresponding generic name.
a.Omeprazole
b.Sucralfate
c.Nizatidine
d.Metoclopramide
e.Calcium carbonate
Reglan

Question 28

MATCHING
Match each of the following trade names with its corresponding generic name.
a.Omeprazole
b.Sucralfate
c.Nizatidine
d.Metoclopramide
e.Calcium carbonate
Prilosec

Question 29

Which of the following pairs of antacids can cause constipation?

A)Calcium and aluminum
B)Magnesium and sodium
C)Calcium and magnesium
D)Sodium and calcium

Question 30

Which of the following warning labels should be placed on a prescription for metoclopramide?

A)May cause confusion.
B)May cause leg cramps.
C)May cause breast tenderness.
D)Do not take with antacids.

Question 31

_____ is currently the only prokinetic drug approved by the FDA.

A)Torsemide
B)Furosemide
C)Metoclopramide
D)Indapamide

Question 32

MATCHING
Match each of the following trade names with its corresponding generic name.
a.Omeprazole
b.Sucralfate
c.Nizatidine
d.Metoclopramide
e.Calcium carbonate
Caltrate

Question 33

_____ drugs are used for the treatment of GERD and LPR because they increase peristalsis.

A)Mucosal protectant
B)Proton pump inhibitors
C)H2 receptor antagonists
D)Prokinetic

Question 34

MATCHING
Match each of the following trade names with its corresponding generic name.
a.Omeprazole
b.Sucralfate
c.Nizatidine
d.Metoclopramide
e.Calcium carbonate
Axid