Deck 9: Immediate-Hypersensitivity

Question 1

Match the definitions in questions with the mast cell mediator (A-G)that most closely matches it.
Biogenic amine that transiently increases vascular permeability and smooth muscle contraction

A)Histamine
B)Tryptase
C)Prostaglandin D2
D)Leukotriene C4
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a

Answer 1

Histamine

Question 2

Immediate hypersensitivity differs from delayed-type hypersensitivity in which one of the following ways?

A)Immediate hypersensitivity is a CD4+ T cell-mediated disease.
B)Immediate hypersensitivity does not require previous exposure to an antigen.
C)Immediate hypersensitivity does not involve inflammation.
D)Immediate hypersensitivity is driven by cytokines such as interleukin (IL)-4,IL-5,and IL-13.
E)Immediate hypersensitivity typically leads to granuloma formation.

Answer 2

Immediate hypersensitivity is driven by cytokines such as interleukin (IL)-4,IL-5,and IL-13.

Question 3

Which of the following is the most common disorder of immunity that affects 20% of all individuals in the United States?

A)Atopy
B)Diabetes mellitus
C)Leukemia
D)IgA deficiency
E)Latent tuberculosis infection

Answer 3

Atopy

Question 4

Match the definitions in questions with the mast cell mediator (A-G)that most closely matches it.
Lipoxygenase-pathway product of arachidonic acid metabolism that causes prolonged bronchoconstriction,mucus secretion,and increased vascular permeability

A)Histamine
B)Tryptase
C)Prostaglandin D2
D)Leukotriene C4
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a

Question 5

Match the definitions in questions with the mast cell mediator (A-G)that most closely matches it.
Soluble factor that promotes inflammation and late-phase reaction and activates endothelial expression of adhesion molecules critical for sequential neutrophilic infiltrate

A)Histamine
B)Tryptase
C)Prostaglandin D2
D)Leukotriene C4
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a

Question 6

Match the definitions in questions with the mast cell mediator (A-G)that most closely matches it.
Protein constituent of granules that contributes to tissue damage in immediate hypersensitivity reactions

A)Histamine
B)Tryptase
C)Prostaglandin D2
D)Leukotriene C4
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a

Question 7

All of the following are key mediators of immediate hypersensitivity reactions EXCEPT:

A)Mast cells
B)Basophils
C)IgE
D)Macrophages
E)TH2 cells

Question 8

Match the definitions in questions with the mast cell mediator (A-G)that most closely matches it.
Membrane phospholipid derivative that causes bronchoconstriction,retraction of endothelial cells,and relaxation of vascular smooth muscle

A)Histamine
B)Tryptase
C)Prostaglandin D2
D)Leukotriene C4
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a

Question 9

Match the definitions in questions with the mast cell mediator (A-G)that most closely matches it.
Cyclooxygenase-pathway product of arachidonic acid metabolism that causes vascular dilatation,smooth muscle contraction,and neutrophil chemotaxis

A)Histamine
B)Tryptase
C)Prostaglandin D2
D)Leukotriene C4
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a

Question 10

Match the definitions in questions with the mast cell mediator (A-G)that most closely matches it.
Soluble factor that promotes eosinophil maturation and activation

A)Histamine
B)Tryptase
C)Prostaglandin D2
D)Leukotriene C4
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a