Genetics: Analysis and Principles 5th Edition by Robert Brooker

Exercise 39

Achondroplasia is a rare form of dwarfism. It is caused by an autosomal dominant mutation within a single gene. Among 1,422,000 live births, the number of babies born with achondroplasia was 31. Among those 31 babies, 18 of them had one parent with achondroplasia. The remaining babies had two unaffected parents. What is the mutation frequency for this disorder among these 1,422,000 babies What is the mutation rate for achondroplasia