Genetics: Analysis and Principles 5th Edition by Robert Brooker

Exercise 37

In the Human Genome Project, researchers have collected linkage data from many crosses in which the male was heterozygous for markers and many crosses where the female was heterozygous for markers. The distance between the same two markers, computed in map units or centiMorgans, is different between males and females. In other words, the linkage maps for human males and females are not the same. Propose an explanation for this discrepancy. Do you think the sizes of chromosomes (excluding the Y chromosome) in human males and females are different How could physical mapping resolve this discrepancy