Essential Genetics 6th Edition by Daniel Hartl

Exercise 9

Protein synthesis occurs with high fidelity. In prokaryotes, incorrect amino acids are inserted at the rate of approximately
(that is, one incorrect amino acid per 1000 translated).
(a) What is the probability that a polypeptide of 300 amino acids has exactly the amino acid sequence specified in the mRNA?
(b) For an active enzyme consisting of four subunits (a tetramer), each 1000 amino acids in length, what is the probability that every amino acid in every subunit is translated without error?