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Molecular Biology Of The Cell 6th Edition by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Edition 6ISBN: 978-0815345244Molecular Biology Of The Cell 6th Edition by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Edition 6ISBN: 978-0815345244 Exercise 5
The origin of new 
cells of the pancreas-from stem cells or from preexisting 
cells-was not resolved until a decade ago, when the technique of lineage tracing was used to decide the issue. Using transgenic mice that expressed a tamoxifen-activated form of Cre recombinase under the control of the insulin promoter, which is active only in 
cells, investigators could remove an inhibitory segment of DNA and thereby allow expression of human placental alkaline phosphatase (HPAP), which can be detected by histochemical staining. After a pulse of tamox- ifen that converted about 30% of 
cells in young mice to cells that express HPAP, the investigators followed the per- centage of labeled 
cells for a year, during which time the total number of 
cells in the pancreas increased by 6.5- fold. How do you suppose the percentage of 
cells would change over time if new 
cells were derived from stem cells? What if new 
cells were derived from preexisting 
cells? WFigure Q22.03/Q22.01hich hypothesis do the results in Figure Q22-2 support? 
cells of the pancreas-from stem cells or from preexisting cells-was not resolved until a decade ago, when the technique of lineage tracing was used to decide the issue. Using transgenic mice that expressed a tamoxifen-activated form of Cre recombinase under the control of the insulin promoter, which is active only in cells, investigators could remove an inhibitory segment of DNA and thereby allow expression of human placental alkaline phosphatase (HPAP), which can be detected by histochemical staining. After a pulse of tamox- ifen that converted about 30% of cells in young mice to cells that express HPAP, the investigators followed the per- centage of labeled cells for a year, during which time the total number of cells in the pancreas increased by 6.5- fold. How do you suppose the percentage of cells would change over time if new cells were derived from stem cells? What if new cells were derived from preexisting cells? WFigure Q22.03/Q22.01hich hypothesis do the results in Figure Q22-2 support? Explanation
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Hematopoietic stem cells have the capaci...
Molecular Biology Of The Cell 6th Edition by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
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