Biomedical Engineering: Bridging Medicine and Technology 1st Edition by Veronique Tran,Mark Saltzman

Exercise 16

One in 1700 U.S. Caucasian newborns has cystic fibrosis. The allele C is normal and dominant over allele c for cystic fibrosis.
a. What percentage of the population has cystic fibrosis?
b. Draw the Punnett square for this gene.
c. From your answer in (a), determine the expected frequencies of all of the genotypes assuming that the population is in Hardy-Weinberg equilib- rium. Hint: calculate q first.
d. How many of the 1700 are homozygous normal?
e. How many in the 1700 are carriers of the cystic fibrosis gene (heterozygous)?