Exam 2: Biologic Aging Theories and Longevity

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Describe the drawbacks of each of the following types of studies on longevity:

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1. Cross-sectional studies: These studies only provide a snapshot of data at a single point in time, so they cannot establish cause and effect relationships. They also do not account for changes in individuals over time, such as lifestyle changes or health improvements.

2. Case-control studies: These studies rely on individuals self-reporting their past behaviors or exposures, which can be unreliable. They also may not accurately represent the general population, as they often rely on specific groups of individuals with a certain condition or outcome.

3. Cohort studies: While cohort studies can provide valuable long-term data, they are expensive and time-consuming to conduct. They also require a large number of participants to account for potential confounding variables, and they may suffer from high dropout rates over time.

4. Randomized controlled trials: These studies are often considered the gold standard for establishing cause and effect relationships, but they can be difficult to conduct in longevity research. Long-term follow-up is needed to assess the effects of interventions on lifespan, and ethical concerns may arise when studying interventions that could potentially harm participants.

Overall, each type of study has its own limitations when it comes to researching longevity, and researchers must carefully consider these drawbacks when designing and interpreting their studies.

It is hypothesized that females have a genetic advantage that enables them to live longer than males in almost all animal species.

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Light drinkers live longer than those who abstain from alcohol altogether.

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It is generally agreed that racial differences in life expectancy are due primarily to genetic factors.

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Programmed aging may be initiated by immune or hormonal systems. Discuss each of these.

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What is the difference between random aging and programmed aging?

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Describe the difference between life span and life expectancy. Which one can individuals influence? Explain how the life expectancy of a 65 year old person is greater than that of a newborn.

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No life extension therapy has been documented to succeed with human subjects.

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How could the "accumulation of errors" influence aging?

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Human life expectancy is relatively constant across history and culture at 115-120 years.

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Which of these characteristics is common among centenarians?

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The most important health habit to increase life expectancy is:

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Thus far, there is no evidence that periodic fasting prolongs life in humans.

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Reducing caloric intake without restricting nutrition increases the length of life in laboratory animals.

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Those who are married live longer than those who are not.

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List three reasons why women typically live longer than men.

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Shorter people live longer than taller people.

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Genes are composed of chromosomes.

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What is the biological clock theory? What is the evidence for this theory?

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How does race and ethnicity affect life expectancy in the United States?

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