Exam 1: Methods of Calculation for Individualized Drug Dosing

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For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.   Give Cytoxan 600 mg/m<sup>2</sup>/wk. Patient height: 70 in , Patient weight: 85 kg What is the weekly dose with  a. square root method? b. nomogram? Give Cytoxan 600 mg/m2/wk. Patient height: 70 in , Patient weight: 85 kg What is the weekly dose with a. square root method? b. nomogram?

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a. 85 kg* 2.2 = 187 lb
 a. 85 kg* 2.2 = 187 lb     600 mg/m<sup>2</sup>/wk * 2.04 m<sup>2</sup> = 1224 or 1225 mg/wk b. Height 70 in, weight 85 kg, intersects 2.08 m<sup>2</sup> 600 mg/m<sup>2</sup>/wk * 2.08 m<sup>2</sup> = 1248  \approx 1250 mg/wk
600 mg/m2/wk * 2.04 m2 = 1224 or 1225 mg/wk
b. Height 70 in, weight 85 kg, intersects 2.08 m2
600 mg/m2/wk * 2.08 m2 = 1248 \approx 1250 mg/wk

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.   Give cisplatinum 80 mg/m<sup>2</sup>/wk. Patient height: 6 ft 2 in , Patient weight: 186 lb What is the weekly dose with  a. square root method? b. nomogram? Give cisplatinum 80 mg/m2/wk. Patient height: 6 ft 2 in , Patient weight: 186 lb What is the weekly dose with a. square root method? b. nomogram?

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a.  a.    80 mg/m<sup>2</sup>/wk *2.09 m<sup>2</sup> = 167.2 mg/wk b. Height 74 in, weight 186 lb, intersects 2.10 m<sup>2</sup> 80 mg/m<sup>2</sup>/wk *2.10 m<sup>2</sup> = 168  \approx  170 mg/wk
80 mg/m2/wk *2.09 m2 = 167.2 mg/wk
b. Height 74 in, weight 186 lb, intersects 2.10 m2
80 mg/m2/wk *2.10 m2 = 168 \approx 170 mg/wk

For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.   Give mitomycin 15 mg/m<sup>2</sup>/week. Patient height: 65 in , Patient weight: 64 kg What is the weekly dose with  a. square root method? b. nomogram? Give mitomycin 15 mg/m2/week. Patient height: 65 in , Patient weight: 64 kg What is the weekly dose with a. square root method? b. nomogram?

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a. 64 kg * 2.2 = 140.8 or 141 lb
 a. 64 kg * 2.2 = 140.8 or 141 lb     15 mg/m<sup>2</sup>/wk * 1.71 m<sup>2</sup> = 25.6 or 26 mg/wk b. Height 65 in, weight 64 kg, intersects 1.75 m<sup>2</sup> 15 mg/m<sup>2</sup>/wk * 1.75 m<sup>2</sup> = 26.25  \approx  26 mg/wk
15 mg/m2/wk * 1.71 m2 = 25.6 or 26 mg/wk
b. Height 65 in, weight 64 kg, intersects 1.75 m2
15 mg/m2/wk * 1.75 m2 = 26.25 \approx 26 mg/wk

Order: clofarabine 52 mg/m2 daily and infuse in 250 mL D5W over 2 hours Patient's height and weight: 5 ft 4 in and 115 lb Drug available: 20 mg/20 mL a. What is the patient's BSA (m2)? b. What is the total dose? c. How many milliliters should you prepare?

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For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.   Give dacarbazine 250 mg/m<sup>2</sup>/day * 5 days. Patient height: 5 ft 10 in , Patient weight: 173 lb What is the daily dose with  a. square root method? b. nomogram? Give dacarbazine 250 mg/m2/day * 5 days. Patient height: 5 ft 10 in , Patient weight: 173 lb What is the daily dose with a. square root method? b. nomogram?

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Order: sargramostim 250 mcg/m2/day, dilute in 50 mL and infuse over 2 hours Patient's height and weight: 5 ft 10 in and 285 lb Drug available: sargramostim 500 mcg/mL a. What is the patient's BSA (m2)? b. What is the total dose? c. How many milliliters should you prepare?

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For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.   Give etoposide 120 mg/m<sup>2</sup>/wk. Patient height: 74 in , Patient weight: 70 kg What is the weekly dose with  a. square root method? b. nomogram? Give etoposide 120 mg/m2/wk. Patient height: 74 in , Patient weight: 70 kg What is the weekly dose with a. square root method? b. nomogram?

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Order: streptozocin 1000 mg/m2 in 100 mL D5W over 2 hours Patient's height and weight: 5 ft 2 in and 210 lb Drug available: streptozocin 1 g powdered vial, reconstitute with 9.5 mL NS; yields 100 mg/mL a. What is the patient's BSA (m2)? b. What is the total dose? c. How many milliliters should you prepare?

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For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.   Give 5-fluorouracil 450 mg/m<sup>2</sup>/wk. Patient height: 5 ft 6 in , Patient weight: 210 lb What is the weekly dose with  a. square root method? b. nomogram? Give 5-fluorouracil 450 mg/m2/wk. Patient height: 5 ft 6 in , Patient weight: 210 lb What is the weekly dose with a. square root method? b. nomogram?

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For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.   Give cytosine arabinoside 100 mg/m<sup>2</sup>/day * 7 days. Patient height: 5 ft 2 in , Patient weight: 130 lb What is the weekly dose with  a. square root method? b. nomogram? Give cytosine arabinoside 100 mg/m2/day * 7 days. Patient height: 5 ft 2 in , Patient weight: 130 lb What is the weekly dose with a. square root method? b. nomogram?

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For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.   Give Adriamycin 60 mg/m<sup>2</sup>/wk. Patient height: 70 in , Patient weight: 80 kg What is the weekly dose with  a. square root method? b. nomogram? Give Adriamycin 60 mg/m2/wk. Patient height: 70 in , Patient weight: 80 kg What is the weekly dose with a. square root method? b. nomogram?

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For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.   Give cytarabine 100 mg/m<sup>2</sup>/day * 7 days. Patient height: 64 in , Patient weight: 65 kg What is the daily dose with  a. square root method? b. nomogram? Give cytarabine 100 mg/m2/day * 7 days. Patient height: 64 in , Patient weight: 65 kg What is the daily dose with a. square root method? b. nomogram?

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Order: cisplatin 50 mg/m2 in 500 mL of NSS intravenously over 90 minutes Patient height and weight: 5 ft 6 in, 160 lb Drug available: cisplatin 100 mg/100 mL a. What is the patient's BSA (m2)? b. What is the total dose? c. How many milliliters should you prepare?

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Order: cyclophosphamide 500 mg/m2 in 500 mL of normal saline solution (NSS) over 90 minutes Patient height and weight: 5 ft 10 in, 142 lb Drug available: cyclophosphamide 100 mg dilute with 5 mL of sterile water; yields 20 mg/mL a. What is the patient's body surface area (BSA) (m2)? b. What is the total dose? c. How many milliliters should you prepare?

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For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.   Give prednisone 60 mg/m<sup>2</sup>/day * 7 days. Patient height: 72 in , Patient weight: 84 kg What is the daily dose with  a. square root method? b. nomogram? Give prednisone 60 mg/m2/day * 7 days. Patient height: 72 in , Patient weight: 84 kg What is the daily dose with a. square root method? b. nomogram?

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For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.   Give idarubicin hydrochloride 12 mg/m<sup>2</sup>/day * 3 days. Patient height: 60 in , Patient weight: 60 kg What is the daily dose with  a. square root method? b. nomogram? Give idarubicin hydrochloride 12 mg/m2/day * 3 days. Patient height: 60 in , Patient weight: 60 kg What is the daily dose with a. square root method? b. nomogram?

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For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.   Give methotrexate 3.3 mg/m<sup>2</sup>/day *7 days. Patient height: 72 in , Patient weight: 82 kg What is the daily dose with  a. square root method? b. nomogram? Give methotrexate 3.3 mg/m2/day *7 days. Patient height: 72 in , Patient weight: 82 kg What is the daily dose with a. square root method? b. nomogram?

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For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.   Give vincristine 2 mg/m<sup>2</sup>/week. Patient height: 62 in , Patient weight: 75 kg What is the weekly dose with  a. square root method? b. nomogram? Give vincristine 2 mg/m2/week. Patient height: 62 in , Patient weight: 75 kg What is the weekly dose with a. square root method? b. nomogram?

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Order: methotrexate 3 mg/m2 PO * 2 weekly Patient's height and weight: 5 ft 2 in and 130 lb Drug available: methotrexate tablets 2.5, 5, 7.5 mg a. What is the patient's BSA (m2)? b. What is the total dose?

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For the following questions, use the square root method and/or nomogram. Note discrepancies between methods. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.   Give cisplatin 30 mg/m<sup>2</sup>/day *3 days. Patient height: 70 in , Patient weight: 80 kg What is the daily dose with  a. square root method? b. nomogram? Give cisplatin 30 mg/m2/day *3 days. Patient height: 70 in , Patient weight: 80 kg What is the daily dose with a. square root method? b. nomogram?

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