Deck 6: Skeletal System: Bones and Bone Tissue
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Deck 6: Skeletal System: Bones and Bone Tissue
1
Which of the following is NOT a function of bone?
A)blood cell formation
B)support
C)calcium storage
D)immunity
E)movement
A)blood cell formation
B)support
C)calcium storage
D)immunity
E)movement
D
2
Which of the following occurs in the formation of mineralized bone matrix?
A)Blood calcium is elevated.
B)Hydrogen ions form an acid environment in bone matrix.
C)Ca2+ is actively transported from bone matrix to the blood.
D)The protein components of bone matrix are digested.
E)Osteoblasts form collagen and proteoglycans.
A)Blood calcium is elevated.
B)Hydrogen ions form an acid environment in bone matrix.
C)Ca2+ is actively transported from bone matrix to the blood.
D)The protein components of bone matrix are digested.
E)Osteoblasts form collagen and proteoglycans.
E
3
The compression (weight-bearing)strength of bone matrix is due to the presence of
A)hydroxyapatite crystals.
B)collagenase.
C)collagen fibers.
D)elastin fibers.
E)bone marrow.
A)hydroxyapatite crystals.
B)collagenase.
C)collagen fibers.
D)elastin fibers.
E)bone marrow.
A
4
The proportion of collagen to hydroxyapatite in bone determines the
A)thickness of the bone.
B)strength of the bone.
C)growth rate of bone.
D)ability of the bone to heal.
E)length of the bone.
A)thickness of the bone.
B)strength of the bone.
C)growth rate of bone.
D)ability of the bone to heal.
E)length of the bone.
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5
Proteoglycan molecules in the matrix of cartilage
A)give cartilage its resilient nature.
B)replace collagen fibers in the matrix.
C)make the perichondrium very stretchable.
D)fill the lacunae.
E)make cartilage hard and compact.
A)give cartilage its resilient nature.
B)replace collagen fibers in the matrix.
C)make the perichondrium very stretchable.
D)fill the lacunae.
E)make cartilage hard and compact.
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6
Rickets is
A)bone inflammation that often results from bacterial infection.
B)a group of genetic disorders producing very brittle bones that are easily fractured; occurs because of insufficient collagen development.
C)a disease in children characterized by soft,bowed,and swollen bones.
D)a disease in adults,especially women,characterized by a reduced amount of bone matrix.
E)a disease in adults characterized by softening of bones resulting from calcium depletion.
A)bone inflammation that often results from bacterial infection.
B)a group of genetic disorders producing very brittle bones that are easily fractured; occurs because of insufficient collagen development.
C)a disease in children characterized by soft,bowed,and swollen bones.
D)a disease in adults,especially women,characterized by a reduced amount of bone matrix.
E)a disease in adults characterized by softening of bones resulting from calcium depletion.
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7
The cell type that is responsible for maintaining bone once it has been formed is the
A)osteocyte.
B)chondrocyte.
C)osteoblast.
D)osteoclast.
E)chondroblast.
A)osteocyte.
B)chondrocyte.
C)osteoblast.
D)osteoclast.
E)chondroblast.
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8
The primary mineral in bone is
A)iron.
B)sodium.
C)potassium.
D)calcium.
E)oxygen.
A)iron.
B)sodium.
C)potassium.
D)calcium.
E)oxygen.
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9
Cartilage
A)is surrounded by a membrane called the periosteum.
B)is composed of osteons.
C)is well vascularized.
D)contains chondrocytes located in lacunae.
E)does not need nutrients and oxygen so it has no blood vessels.
A)is surrounded by a membrane called the periosteum.
B)is composed of osteons.
C)is well vascularized.
D)contains chondrocytes located in lacunae.
E)does not need nutrients and oxygen so it has no blood vessels.
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10
Collagen and calcium hydroxyapatite are the primary constituents of
A)bone matrix.
B)blood.
C)fibrous cartilage.
D)hyaline cartilage.
E)ligaments.
A)bone matrix.
B)blood.
C)fibrous cartilage.
D)hyaline cartilage.
E)ligaments.
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11
Which of the following matrix molecules in cartilage tends to trap large quantities of water?
A)proteoglycan
B)hyaluronic acid
C)elastin
D)collagen
E)chondrocytes
A)proteoglycan
B)hyaluronic acid
C)elastin
D)collagen
E)chondrocytes
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12
Chondroblasts produce
A)ligaments.
B)blood cells.
C)bone tissue.
D)cartilage matrix.
E)synovial fluid.
A)ligaments.
B)blood cells.
C)bone tissue.
D)cartilage matrix.
E)synovial fluid.
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13
Osteogenesis imperfecta can be caused by abnormally formed
A)hydroxyapatite.
B)proteoglycans.
C)collagen.
D)osteoblasts.
E)calcium.
A)hydroxyapatite.
B)proteoglycans.
C)collagen.
D)osteoblasts.
E)calcium.
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14
In appositional growth of cartilage,
A)new chondrocytes and new matrix are added on the outside of the tissue.
B)the tissue becomes vascularized in order to grow.
C)chondroblasts within the tissue proliferate and add more matrix from the inside.
D)the cartilage is replaced with another kind of connective tissue.
E)osteoblasts replace the chondroblasts.
A)new chondrocytes and new matrix are added on the outside of the tissue.
B)the tissue becomes vascularized in order to grow.
C)chondroblasts within the tissue proliferate and add more matrix from the inside.
D)the cartilage is replaced with another kind of connective tissue.
E)osteoblasts replace the chondroblasts.
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15
Ligaments attach
A)muscle to bone.
B)nerve to muscle.
C)bone to bone.
D)muscle to muscle.
E)nerve to bone.
A)muscle to bone.
B)nerve to muscle.
C)bone to bone.
D)muscle to muscle.
E)nerve to bone.
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16
The connective tissue sheath of cartilage is called the
A)ligamentous cord.
B)lacuna.
C)chondrocyte.
D)matrix.
E)perichondrium.
A)ligamentous cord.
B)lacuna.
C)chondrocyte.
D)matrix.
E)perichondrium.
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17
A band of connective tissue that attaches a muscle to a bone is a(n)
A)bursa.
B)aponeurosis.
C)epimysium.
D)tendon.
E)ligament.
A)bursa.
B)aponeurosis.
C)epimysium.
D)tendon.
E)ligament.
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18
Brittle bone disorder is another name for
A)scurvy.
B)osteomyelitis.
C)osteoporosis.
D)osteomalacia.
E)osteogenesis imperfecta.
A)scurvy.
B)osteomyelitis.
C)osteoporosis.
D)osteomalacia.
E)osteogenesis imperfecta.
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19
The type of cartilage associated with bone function and development is
A)osteocartilage.
B)elastic cartilage.
C)hyaline cartilage.
D)interstitial cartilage.
E)fibrocartilage.
A)osteocartilage.
B)elastic cartilage.
C)hyaline cartilage.
D)interstitial cartilage.
E)fibrocartilage.
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20
A connective tissue sheath around cartilage is the
A)periosteum.
B)ligament.
C)endosteum.
D)epiphyseal line.
E)perichondrium.
A)periosteum.
B)ligament.
C)endosteum.
D)epiphyseal line.
E)perichondrium.
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21
Which type of bone cells lie in lacunae?
A)osteocytes
B)osteoblasts
C)osteoclasts
D)osteochondral progenitor cell
A)osteocytes
B)osteoblasts
C)osteoclasts
D)osteochondral progenitor cell
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22
Haversian systems or osteons
A)lack concentric lamellae.
B)do not contain osteocytes.
C)are found in spongy bone tissue.
D)are avascular.
E)are the basic units in compact bone tissue.
A)lack concentric lamellae.
B)do not contain osteocytes.
C)are found in spongy bone tissue.
D)are avascular.
E)are the basic units in compact bone tissue.
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23
Which of the following is associated with osteoclast reabsorption of bone?
A)Osteoblasts form collagen and proteoglycans.
B)Blood calcium is decreased.
C)Ca2+ is actively transported from blood to bone matrix.
D)Hydrogen ions form an acid environment in bone matrix.
E)The protein components of bone matrix are synthesized.
A)Osteoblasts form collagen and proteoglycans.
B)Blood calcium is decreased.
C)Ca2+ is actively transported from blood to bone matrix.
D)Hydrogen ions form an acid environment in bone matrix.
E)The protein components of bone matrix are synthesized.
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24
Spongy bone tissue
A)contains interconnecting plates called trabeculae.
B)is very dense.
C)contains concentric lamellae.
D)is the primary component of compact bone.
E)has many spaces and lacks osteocytes.
A)contains interconnecting plates called trabeculae.
B)is very dense.
C)contains concentric lamellae.
D)is the primary component of compact bone.
E)has many spaces and lacks osteocytes.
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25
The primary function of osteoblasts is to
A)inhibit the growth of bone.
B)lay down bone matrix.
C)resorb bone along the epiphyseal plate.
D)prevent osteocytes from forming.
E)stimulate bone growth.
A)inhibit the growth of bone.
B)lay down bone matrix.
C)resorb bone along the epiphyseal plate.
D)prevent osteocytes from forming.
E)stimulate bone growth.
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26
Lamellar bone
A)is very light in weight.
B)has a porous appearance.
C)has its collagen fibers randomly oriented.
D)is organized into thin sheets of tissue.
E)is not easily restructured.
A)is very light in weight.
B)has a porous appearance.
C)has its collagen fibers randomly oriented.
D)is organized into thin sheets of tissue.
E)is not easily restructured.
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27
Which of the following cell types is responsible for breaking down bone matrix?
A)osteoclast
B)fibroblast
C)osteocyte
D)chondroclast
E)chondroblast
A)osteoclast
B)fibroblast
C)osteocyte
D)chondroclast
E)chondroblast
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28
Which of the following is correctly matched?
A)periosteum - lines the medullary cavity
B)osteoblasts - break down bone tissue
C)osteoclasts - responsible for reabsorption
D)endosteum - lines central canal of the osteon
E)osteocytes - function in bone remodeling
A)periosteum - lines the medullary cavity
B)osteoblasts - break down bone tissue
C)osteoclasts - responsible for reabsorption
D)endosteum - lines central canal of the osteon
E)osteocytes - function in bone remodeling
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29
Woven bone
A)has a porous appearance.
B)is not easily restructured.
C)has its collagen fibers randomly oriented.
D)is organized into thin sheets of tissue.
E)is very light in weight.
A)has a porous appearance.
B)is not easily restructured.
C)has its collagen fibers randomly oriented.
D)is organized into thin sheets of tissue.
E)is very light in weight.
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30
Which type of bone cells possess extensive ER and ribosomes?
A)osteocytes
B)osteoblasts
C)osteoclasts
D)osteochondral progenitor cell
A)osteocytes
B)osteoblasts
C)osteoclasts
D)osteochondral progenitor cell
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31
Which type of bone cells are large cells that form from fusion of monocytes?
A)osteochondral progenitor cell
B)osteocytes
C)osteoblasts
D)osteoclasts
A)osteochondral progenitor cell
B)osteocytes
C)osteoblasts
D)osteoclasts
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32
Which type of bone cells package calcium and phosphate ions?
A)osteochondral progenitor cell
B)osteoclasts
C)osteoblasts
D)osteocytes
A)osteochondral progenitor cell
B)osteoclasts
C)osteoblasts
D)osteocytes
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33
Which type of bone cells have processes that lie in canaliculi?
A)osteocytes
B)osteoblasts
C)osteoclasts
D)osteochondral progenitor cell
A)osteocytes
B)osteoblasts
C)osteoclasts
D)osteochondral progenitor cell
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34
Which type of bone cells combine hydroxyapatite and collagen to form extracellular bone matrix?
A)osteochondral progenitor cell
B)osteoblasts
C)osteocytes
D)osteoclasts
A)osteochondral progenitor cell
B)osteoblasts
C)osteocytes
D)osteoclasts
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35
The stem cells of osteoclasts are
A)osteocytes.
B)chondrocytes.
C)monocytes.
D)osteochondral progenitor cells.
E)osteoclasts.
A)osteocytes.
B)chondrocytes.
C)monocytes.
D)osteochondral progenitor cells.
E)osteoclasts.
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36
Which type of bone cells have ruffled borders and secrete acids?
A)osteoblasts
B)osteochondral progenitor cell
C)osteoclasts
D)osteocytes
A)osteoblasts
B)osteochondral progenitor cell
C)osteoclasts
D)osteocytes
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37
Osteoclasts have projections that cause bone reabsorption called
A)ruffled borders.
B)canaliculi.
C)lacunae.
D)crossroads.
E)lamellae.
A)ruffled borders.
B)canaliculi.
C)lacunae.
D)crossroads.
E)lamellae.
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38
What are the maintenance cells in bone tissue?
A)osteochondral progenitor cells
B)chondrocytes
C)osteoblasts
D)osteocytes
E)osteoclasts
A)osteochondral progenitor cells
B)chondrocytes
C)osteoblasts
D)osteocytes
E)osteoclasts
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39
Which type of bone cells give rise to osteoblasts?
A)osteochondral progenitor cell
B)osteoblasts
C)osteoclasts
D)osteocytes
A)osteochondral progenitor cell
B)osteoblasts
C)osteoclasts
D)osteocytes
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40
The stem cells of osteoblasts and chondroblasts are
A)monocytes.
B)chondrocytes.
C)osteocytes.
D)osteoclasts.
E)osteochondral progenitor cells.
A)monocytes.
B)chondrocytes.
C)osteocytes.
D)osteoclasts.
E)osteochondral progenitor cells.
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41
Thin sheets of bone matrix are
A)lamellae.
B)lacunae.
C)trabeculae.
D)periosteum.
E)canaliculi.
A)lamellae.
B)lacunae.
C)trabeculae.
D)periosteum.
E)canaliculi.
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42
In which type of bone would trabeculae be present?
A)spongy bone
B)compact bone
C)both spongy and compact
A)spongy bone
B)compact bone
C)both spongy and compact
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43
In which type of bone would osteons be present?
A)compact bone
B)spongy bone
C)both spongy and compact
A)compact bone
B)spongy bone
C)both spongy and compact
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44
Which type of bone has concentric lamellae?
A)compact bone
B)both spongy and compact
C)spongy bone
A)compact bone
B)both spongy and compact
C)spongy bone
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45
An example of a long bone would be
A)the sternum.
B)the tibia.
C)a rib.
D)the clavicle.
E)a carpal bone.
A)the sternum.
B)the tibia.
C)a rib.
D)the clavicle.
E)a carpal bone.
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46
The type of lamellae that forms the outside surface of compact bone is
A)interstitial.
B)circumferential.
C)appositional.
D)concentric.
E)oppositional.
A)interstitial.
B)circumferential.
C)appositional.
D)concentric.
E)oppositional.
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47
Interconnecting rods of bone are
A)periosteum.
B)trabeculae.
C)lamellae.
D)canaliculi.
E)lacunae.
A)periosteum.
B)trabeculae.
C)lamellae.
D)canaliculi.
E)lacunae.
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48
These are blood vessels that carry blood from the medullary cavity and periosteum to the osteon and run perpendicular to the long axis of the bone.
A)Haversian canals
B)lamellar canals
C)Volkmann canals
D)osteochondral canals
E)Sharpey's canals
A)Haversian canals
B)lamellar canals
C)Volkmann canals
D)osteochondral canals
E)Sharpey's canals
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49
The type of lamellae found between osteons (Haversian systems)is
A)interstitial.
B)oppositional.
C)appositional.
D)circumferential.
E)concentric.
A)interstitial.
B)oppositional.
C)appositional.
D)circumferential.
E)concentric.
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50
A passageway connecting neighboring osteocytes in an osteon is a
A)lacuna.
B)lamella.
C)osteocanal.
D)canaliculus.
E)central canal.
A)lacuna.
B)lamella.
C)osteocanal.
D)canaliculus.
E)central canal.
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51
Which of the following is correctly matched?
A)short bone - carpal bone
B)long bone - vertebra
C)short bone - humerus
D)flat bone - phalanges of the toes
E)irregular bone - femur
A)short bone - carpal bone
B)long bone - vertebra
C)short bone - humerus
D)flat bone - phalanges of the toes
E)irregular bone - femur
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52
Canaliculi are found in this type of bone tissue.
A)compact bone
B)both spongy and compact
C)spongy bone
A)compact bone
B)both spongy and compact
C)spongy bone
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53
Spaces in the bone matrix that are occupied by osteocytes are
A)periosteum.
B)trabeculae.
C)lacunae.
D)lamellae.
A)periosteum.
B)trabeculae.
C)lacunae.
D)lamellae.
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54
Which type of bone is considered dense bone?
A)compact bone
B)spongy bone
C)both spongy and compact
A)compact bone
B)spongy bone
C)both spongy and compact
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55
You would look for concentric lamellae
A)as components of the cartilage.
B)in between osteons.
C)around the central canal of an osteon.
D)on the outer surface of compact bone tissues.
E)in the bone marrow.
A)as components of the cartilage.
B)in between osteons.
C)around the central canal of an osteon.
D)on the outer surface of compact bone tissues.
E)in the bone marrow.
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56
In which type of bone are osteoblasts and osteoclasts present?
A)spongy bone
B)compact bone
C)both spongy and compact
A)spongy bone
B)compact bone
C)both spongy and compact
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57
The covering of the outer surface of bone is the
A)trabeculae.
B)lamellae.
C)lacunae.
D)periosteum.
E)canaliculi.
A)trabeculae.
B)lamellae.
C)lacunae.
D)periosteum.
E)canaliculi.
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58
Small channels extending through the bone matrix are
A)lacunae.
B)lamellae.
C)canaliculi.
D)periosteum.
E)trabeculae.
A)lacunae.
B)lamellae.
C)canaliculi.
D)periosteum.
E)trabeculae.
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59
Which type of bone appears porous?
A)spongy bone
B)compact bone
C)both spongy and compact
A)spongy bone
B)compact bone
C)both spongy and compact
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60
The type of lamellae found in osteons (Haversian systems)is
A)circumferential.
B)interstitial.
C)appositional.
D)concentric.
E)oppositional.
A)circumferential.
B)interstitial.
C)appositional.
D)concentric.
E)oppositional.
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61
Which of the following membranes covers the surface of a mature bone?
A)perichondrium
B)perimysium
C)periosteum
D)peritendineum
E)peritoneum
A)perichondrium
B)perimysium
C)periosteum
D)peritendineum
E)peritoneum
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62
An X-ray determines that Peter fractured the shaft of his humerus.The break is in the _____________ of the bone.
A)diaphysis
B)epiphyseal line
C)articular surface
D)epiphysis
E)growth plate
A)diaphysis
B)epiphyseal line
C)articular surface
D)epiphysis
E)growth plate
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63
What is the membrane that lines the medullary cavity?
A)fibers
B)endosteum
C)growth plate
D)medullary cavity
E)epiphysis
A)fibers
B)endosteum
C)growth plate
D)medullary cavity
E)epiphysis
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64
The locations where ossification begins in intramembranous ossification are known as
A)centers of ossification.
B)membranous ossification centers.
C)epiphyseal ossification centers.
D)secondary ossification centers.
E)medullary cavity ossification centers.
A)centers of ossification.
B)membranous ossification centers.
C)epiphyseal ossification centers.
D)secondary ossification centers.
E)medullary cavity ossification centers.
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65
The medullary cavity is
A)the site where osteoblasts are found.
B)filled with fibrocartilage and elastin fibers.
C)dead space in the bone.
D)lined with endosteum.
E)empty in adult bones.
A)the site where osteoblasts are found.
B)filled with fibrocartilage and elastin fibers.
C)dead space in the bone.
D)lined with endosteum.
E)empty in adult bones.
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66
Which of the following events occurs last in intramembranous ossification?
A)Cancellous bone is formed.
B)Periosteum is formed.
C)Many tiny trabeculae of woven bone develop.
D)A membrane of delicate collagen fibers develops.
E)Osteoprogenitor cells become osteoblasts.
A)Cancellous bone is formed.
B)Periosteum is formed.
C)Many tiny trabeculae of woven bone develop.
D)A membrane of delicate collagen fibers develops.
E)Osteoprogenitor cells become osteoblasts.
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67
What is the site of longitudinal growth in long bones?
A)epiphyseal plate
B)epiphysis
C)medullary cavity
D)Sharpey's fibers
E)endosteum
A)epiphyseal plate
B)epiphysis
C)medullary cavity
D)Sharpey's fibers
E)endosteum
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68
These collagen fibers help to connect ligaments and tendons to the periosteum of the bone.
A)Purkinje fibers
B)Golgi fibers
C)Sharpey fibers
D)Haversian fibers
E)endosteal fibers
A)Purkinje fibers
B)Golgi fibers
C)Sharpey fibers
D)Haversian fibers
E)endosteal fibers
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69
The flat bones of the skull develop from
A)fibrous connective tissue.
B)fibrocartilage.
C)compact bone.
D)hyaline cartilage.
E)areolar tissue.
A)fibrous connective tissue.
B)fibrocartilage.
C)compact bone.
D)hyaline cartilage.
E)areolar tissue.
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70
What strengthens the attachment of the tendons or ligaments to bone?
A)growth plate
B)epiphysis
C)Sharpey fibers
D)medullary cavity
E)endosteum
A)growth plate
B)epiphysis
C)Sharpey fibers
D)medullary cavity
E)endosteum
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71
Arrange the following events in endochondral ossification in proper sequence: (1)Cartilage matrix is calcified and chondrocytes die.
(2)Chondrocytes hypertrophy.
(3)Cartilage model is formed.
(4)Osteoblasts deposit bone on the surface of the calcified cartilage called the primary ossification center.
(5)Blood vessels from the periosteum invade calcified cartilage bringing in osteoblasts and osteoclasts.
A)3,2,1,5,4
B)3,5,2,4,1
C)3,2,5,1,4
D)1,3,4,5,2
E)3,2,5,4,1
(2)Chondrocytes hypertrophy.
(3)Cartilage model is formed.
(4)Osteoblasts deposit bone on the surface of the calcified cartilage called the primary ossification center.
(5)Blood vessels from the periosteum invade calcified cartilage bringing in osteoblasts and osteoclasts.
A)3,2,1,5,4
B)3,5,2,4,1
C)3,2,5,1,4
D)1,3,4,5,2
E)3,2,5,4,1
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72
What is the end of a long bone?
A)endosteum
B)growth plate
C)Sharpey's fibers
D)epiphysis
E)medullary cavity
A)endosteum
B)growth plate
C)Sharpey's fibers
D)epiphysis
E)medullary cavity
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73
Intramembranous ossification
A)occurs when osteoblasts invade the spaces left by dying cartilage cells.
B)forms the bones of the roof of the skull.
C)occurs on the outer surface of the membrane.
D)is the process that produces most of the skeletal system.
E)occurs when bones develop from cartilage models.
A)occurs when osteoblasts invade the spaces left by dying cartilage cells.
B)forms the bones of the roof of the skull.
C)occurs on the outer surface of the membrane.
D)is the process that produces most of the skeletal system.
E)occurs when bones develop from cartilage models.
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74
What is the site of long bone growth?
A)endosteum
B)epiphyseal plate
C)medullary cavity
D)periosteum
E)diaphysis
A)endosteum
B)epiphyseal plate
C)medullary cavity
D)periosteum
E)diaphysis
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75
What type of tissue covers the ends of long bones?
A)articular cartilage
B)fibrocartilage
C)cancellous bone
D)elastic cartilage
E)periosteum
A)articular cartilage
B)fibrocartilage
C)cancellous bone
D)elastic cartilage
E)periosteum
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76
Ossification that involves replacing cartilage with bone is
A)interstitial.
B)endochondral.
C)intramembranous.
D)osteomalacia.
E)appositional.
A)interstitial.
B)endochondral.
C)intramembranous.
D)osteomalacia.
E)appositional.
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77
Some flat and irregular bones of the skull have air-filled spaces called
A)sinuses.
B)trabeculae.
C)epiphyseal spaces.
D)medullary cavities.
E)lacunae.
A)sinuses.
B)trabeculae.
C)epiphyseal spaces.
D)medullary cavities.
E)lacunae.
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78
What is the area where marrow is located?
A)endosteum
B)Sharpey fibers
C)periosteum
D)medullary cavity
E)growth plate
A)endosteum
B)Sharpey fibers
C)periosteum
D)medullary cavity
E)growth plate
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79
The spaces between developing skull bones that have not ossified are called
A)epiphyseal plates.
B)bone collars.
C)articular cartilages.
D)fontanels.
E)medullary cavities.
A)epiphyseal plates.
B)bone collars.
C)articular cartilages.
D)fontanels.
E)medullary cavities.
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80
The processes of intramembranous and endochondral ossification are similar in several respects.Which of the following statements applies to both intramembranous and endochondral ossification?
A)Both processes require a precursor of connective tissue membranes.
B)Both processes form woven bone.
C)Both only form flat bones.
D)Chondrocytes participate in both processes.
E)In both processes,bone replaces cartilage.
A)Both processes require a precursor of connective tissue membranes.
B)Both processes form woven bone.
C)Both only form flat bones.
D)Chondrocytes participate in both processes.
E)In both processes,bone replaces cartilage.
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