Deck 9: P53 and Apoptosis: Master Guardian and Executioner

Question 1

DNA damage may result in all of the following EXCEPT

A)Increased activation of ATM.
B)Increased activation of Chk1/Chk2.
C)Increased levels of p53 protein.
D)DNA double strand breaks.
E)Ubiquitylation of p53.

Answer 1

Ubiquitylation of p53.

Question 2

The process of formation of new blood vessels is called

A)Leukemogenesis.
B)Hematopoiesis.
C)Vasculogenesis.
D)Thrombopoiesis.
E)Angiogenesis.

Answer 2

Angiogenesis.

Question 3

Which of the following results in an increase in the levels of p53 protein?

A)Oncogenic signaling
B)UV radiation
C)Ionizing radiation
D)Hypoxia
E)All of the above

Answer 3

All of the above

Question 4

Increased expression of MDM2 may result in

A)Increased expression of p53.
B)Apoptosis.
C)Cell cycle arrest.
D)Degradation of p53.
E)Senescence.

Question 5

An irreversible arrest in the cell cycle resulting in a viable but nongrowing state is known as

A)The arrest point.
B)Senescence.
C)Quiescence.
D)Inactivation.
E)Involution.

Question 6

The cell's latent suicide program,resulting in rapid cell death,is called

A)Apoptosis.
B)Necrosis.
C)Eradication.
D)Ischemia.
E)Caspase.

Question 7

p53 signaling may result in all of the following EXCEPT

A)Apoptosis.
B)Senescence.
C)Angiogenesis.
D)DNA repair.
E)Cytostatic response.

Question 8

Which of the following proteins may INHIBIT apoptosis?

A)Bcl-2
B)Caspase-9
C)Lamin
D)Apaf-1
E)Noxa

Question 9

Which of the following scenarios will NOT result in an increase in apoptotic activity?

A)Overexpression of Noxa
B)Inhibition of Bcl-2 signaling
C)Phosphorylation of Bim
D)Activation of caspase-9
E)Flux in cellular calcium levels

Question 10

Which of the following types of p53 mutations would be MOST beneficial to a tumor cell?

A)Splice site change.
B)Premature stop codon.
C)Silent mutation.
D)Frameshift.
E)Missense mutation.

Question 11

Which of the following is NOT true of p53?

A)Most tumor-associated p53 mutations are the result of nonsense codons.
B)p53 is mutated in over 30-50% of all cancers.
C)Normal p53 functions as a "tumor suppressor."
D)Mice lacking p53 are viable.
E)Exposure to UV radiation results in increased expression of p53.

Question 12

Apoptotic cell death can be induced by

A)p53 signaling.
B)Signaling from surface cell death receptors.
C)Extracellular stresses.
D)A,B,and C.
E)None of the above.

Question 13

Release of cytochrome c from the mitochondrial membrane is stimulated by

A)Bcl-2 and Bcl-X_L.
B)Bax and Bad.
C)Bcl-W and Mcl-1.
D)Caspase-9.
E)None of the above.

Question 14

The p14^ARF protein may be activated in response to all of the following EXCEPT

A)Ras signaling.
B)Increased levels of E1A.
C)Decreased activity of E2F transcription factors.
D)C-Myc signaling.
E)None of the above.

Question 15

Which of the following proteins has a BH4 domain?

A)Bax
B)Bid
C)Puma
D)Bcl-2
E)Hrk

Question 16

Which of the following types of alterations would NOT promote tumorigenesis?

A)Overexpression of MDM2
B)Overexpression of Bak
C)Overexpression of Bcl-2
D)Defective Chk2 kinase signaling
E)Increased activation of PI3K