Question 1

Which of the following types of alterations would NOT promote tumorigenesis?

Accepted Answer

A) Overexpression of MDM2 
B) Overexpression of Bak 
C) Overexpression of Bcl-2 
D) Defective Chk2 kinase signaling 
E) Increased activation of PI3K 
A) Overexpression of MDM2 
B) Overexpression of Bak 
C) Overexpression of Bcl-2 
D) Defective Chk2 kinase signaling 
E) Increased activation of PI3K B

Question 2

DNA damage may result in all of the following EXCEPT

Accepted Answer

A) Increased activation of ATM. 
B) Increased activation of Chk1/Chk2. 
C) Increased levels of p53 protein. 
D) DNA double strand breaks. 
E) Ubiquitylation of p53. 
A) Increased activation of ATM. 
B) Increased activation of Chk1/Chk2. 
C) Increased levels of p53 protein. 
D) DNA double strand breaks. 
E) Ubiquitylation of p53. E

Question 3

Which of the following results in an increase in the levels of p53 protein?

Accepted Answer

A) Oncogenic signaling 
B) UV radiation 
C) Ionizing radiation 
D) Hypoxia 
E) All of the above 
A) Oncogenic signaling 
B) UV radiation 
C) Ionizing radiation 
D) Hypoxia 
E) All of the above E

Question 4

The p14ARF protein may be activated in response to all of the following EXCEPT

Accepted Answer

A) Ras signaling. 
B) Increased levels of E1A. 
C) Decreased activity of E2F transcription factors. 
D) C-Myc signaling. 
E) None of the above. 
A) Ras signaling. 
B) Increased levels of E1A. 
C) Decreased activity of E2F transcription factors. 
D) C-Myc signaling. 
E) None of the above.

Question 5

Which of the following is NOT true of p53?

Accepted Answer

A) Most tumor-associated p53 mutations are the result of nonsense codons. 
B) p53 is mutated in over 30-50% of all cancers. 
C) Normal p53 functions as a "tumor suppressor." 
D) Mice lacking p53 are viable. 
E) Exposure to UV radiation results in increased expression of p53. 
A) Most tumor-associated p53 mutations are the result of nonsense codons. 
B) p53 is mutated in over 30-50% of all cancers. 
C) Normal p53 functions as a "tumor suppressor." 
D) Mice lacking p53 are viable. 
E) Exposure to UV radiation results in increased expression of p53.

Question 6

Which of the following proteins has a BH4 domain?

Accepted Answer

A) Bax 
B) Bid 
C) Puma 
D) Bcl-2 
E) Hrk 
A) Bax 
B) Bid 
C) Puma 
D) Bcl-2 
E) Hrk

Question 7

Apoptotic cell death can be induced by

Accepted Answer

A) p53 signaling. 
B) Signaling from surface cell death receptors. 
C) Extracellular stresses. 
D) A,B,and C. 
E) None of the above. 
A) p53 signaling. 
B) Signaling from surface cell death receptors. 
C) Extracellular stresses. 
D) A,B,and C. 
E) None of the above.

Question 8

The cell's latent suicide program,resulting in rapid cell death,is called

Accepted Answer

A) Apoptosis. 
B) Necrosis. 
C) Eradication. 
D) Ischemia. 
E) Caspase. 
A) Apoptosis. 
B) Necrosis. 
C) Eradication. 
D) Ischemia. 
E) Caspase.

Question 9

Release of cytochrome c from the mitochondrial membrane is stimulated by

Accepted Answer

A) Bcl-2 and Bcl-XL. 
B) Bax and Bad. 
C) Bcl-W and Mcl-1. 
D) Caspase-9. 
E) None of the above. 
A) Bcl-2 and Bcl-XL. 
B) Bax and Bad. 
C) Bcl-W and Mcl-1. 
D) Caspase-9. 
E) None of the above.

Question 10

The process of formation of new blood vessels is called

Accepted Answer

A) Leukemogenesis. 
B) Hematopoiesis. 
C) Vasculogenesis. 
D) Thrombopoiesis. 
E) Angiogenesis. 
A) Leukemogenesis. 
B) Hematopoiesis. 
C) Vasculogenesis. 
D) Thrombopoiesis. 
E) Angiogenesis.

Question 11

Which of the following types of p53 mutations would be MOST beneficial to a tumor cell?

Accepted Answer

A) Splice site change. 
B) Premature stop codon. 
C) Silent mutation. 
D) Frameshift. 
E) Missense mutation. 
A) Splice site change. 
B) Premature stop codon. 
C) Silent mutation. 
D) Frameshift. 
E) Missense mutation.

Question 12

p53 signaling may result in all of the following EXCEPT

Accepted Answer

A) Apoptosis. 
B) Senescence. 
C) Angiogenesis. 
D) DNA repair. 
E) Cytostatic response. 
A) Apoptosis. 
B) Senescence. 
C) Angiogenesis. 
D) DNA repair. 
E) Cytostatic response.

Question 13

An irreversible arrest in the cell cycle resulting in a viable but nongrowing state is known as

Accepted Answer

A) The arrest point. 
B) Senescence. 
C) Quiescence. 
D) Inactivation. 
E) Involution. 
A) The arrest point. 
B) Senescence. 
C) Quiescence. 
D) Inactivation. 
E) Involution.

Question 14

Which of the following scenarios will NOT result in an increase in apoptotic activity?

Accepted Answer

A) Overexpression of Noxa 
B) Inhibition of Bcl-2 signaling 
C) Phosphorylation of Bim 
D) Activation of caspase-9 
E) Flux in cellular calcium levels 
A) Overexpression of Noxa 
B) Inhibition of Bcl-2 signaling 
C) Phosphorylation of Bim 
D) Activation of caspase-9 
E) Flux in cellular calcium levels

Question 15

Which of the following proteins may INHIBIT apoptosis?

Accepted Answer

A) Bcl-2 
B) Caspase-9 
C) Lamin 
D) Apaf-1 
E) Noxa 
A) Bcl-2 
B) Caspase-9 
C) Lamin 
D) Apaf-1 
E) Noxa

Question 16

Increased expression of MDM2 may result in

Accepted Answer

A) Increased expression of p53. 
B) Apoptosis. 
C) Cell cycle arrest. 
D) Degradation of p53. 
E) Senescence. 
A) Increased expression of p53. 
B) Apoptosis. 
C) Cell cycle arrest. 
D) Degradation of p53. 
E) Senescence.

Which of the following types of alterations would NOT promote tumorigenesis?

DNA damage may result in all of the following EXCEPT

Which of the following results in an increase in the levels of p53 protein?

The p14^ARF protein may be activated in response to all of the following EXCEPT

Which of the following is NOT true of p53?

Which of the following proteins has a BH4 domain?

Apoptotic cell death can be induced by

The cell's latent suicide program,resulting in rapid cell death,is called

Release of cytochrome c from the mitochondrial membrane is stimulated by

The process of formation of new blood vessels is called

Which of the following types of p53 mutations would be MOST beneficial to a tumor cell?

p53 signaling may result in all of the following EXCEPT

An irreversible arrest in the cell cycle resulting in a viable but nongrowing state is known as

Which of the following scenarios will NOT result in an increase in apoptotic activity?

Which of the following proteins may INHIBIT apoptosis?

Increased expression of MDM2 may result in

The Biology and Genetics of Cells and Organisms

The Nature of Cancer

Tumor Viruses

Cellular Oncogenes

Growth Factors,receptors,and Cancer

Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer

Tumor Suppressor Genes

Prb and Control of the Cell Cycle Clock

Eternal Life: Cell Immortalization and Tumorigenesis

Multi-Step Tumorigenesis

Maintenance of Genomic Integrity and the Development of Cancer

Dialogue Replaces Monologue: Heterotypic Interactions and the Biology of Angiogenesis

Moving Out: Invasion and Metastasis

Crowd Control: Tumor Immunology and Immunotherapy

The Rational Treatment of Cancer

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Exam 9: P53 and Apoptosis: Master Guardian and Executioner

Which of the following types of alterations would NOT promote tumorigenesis?

DNA damage may result in all of the following EXCEPT

Which of the following results in an increase in the levels of p53 protein?

The p14ARF protein may be activated in response to all of the following EXCEPT

Which of the following is NOT true of p53?

Which of the following proteins has a BH4 domain?

Apoptotic cell death can be induced by

The cell's latent suicide program,resulting in rapid cell death,is called

Release of cytochrome c from the mitochondrial membrane is stimulated by

The process of formation of new blood vessels is called

Which of the following types of p53 mutations would be MOST beneficial to a tumor cell?

p53 signaling may result in all of the following EXCEPT

An irreversible arrest in the cell cycle resulting in a viable but nongrowing state is known as

Which of the following scenarios will NOT result in an increase in apoptotic activity?

Which of the following proteins may INHIBIT apoptosis?

Increased expression of MDM2 may result in

The Biology and Genetics of Cells and Organisms

The Nature of Cancer

Tumor Viruses

Cellular Oncogenes

Growth Factors,receptors,and Cancer

Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer

Tumor Suppressor Genes

Prb and Control of the Cell Cycle Clock

Eternal Life: Cell Immortalization and Tumorigenesis

Multi-Step Tumorigenesis

Maintenance of Genomic Integrity and the Development of Cancer

Dialogue Replaces Monologue: Heterotypic Interactions and the Biology of Angiogenesis

Moving Out: Invasion and Metastasis

Crowd Control: Tumor Immunology and Immunotherapy

The Rational Treatment of Cancer

Filters

The p14^ARF protein may be activated in response to all of the following EXCEPT