Deck 18: Immunoproliferative Diseases

Question 1

Which of the following findings is a diagnostic criterion for monoclonal gammopathy of undetermined significance?

A) Serum monoclonal protein greater than 3 g/dL
B) Plasma cell count lower than 10% of total cells in bone marrow
C) Increased calcium in the blood
D) Presence of CRAB features

Answer 1

Plasma cell count lower than 10% of total cells in bone marrow

Question 2

Which of the following is not a characteristic in the identification of lymphoma of B-cell origin?

A) Surface immunoglobulins
B) Cell-surface proteins CD19 and CD20
C) Rearrangement of immunoglobulin genes
D) Presence of CD14 and CD15

Answer 2

Presence of CD14 and CD15

Question 3

What is the correct order of protein migration,starting at the cathode and moving to anode,following serum protein electrophoresis?

A) Albumin, gamma, alpha 1, alpha 2, beta
B) Albumin, alpha 1, alpha 2, beta, and gamma
C) Gamma, beta, alpha 2, alpha 1, albumin
D) Beta, gamma, alpha 2, and alpha 1, albumin

Answer 3

Gamma, beta, alpha 2, alpha 1, albumin

Question 4

Malignant plasma cells exhibiting CD38,CD56,and CD138 are found in:

A) Waldenström macroglobulinemia.
B) chronic myeloid leukemia.
C) multiple myeloma.
D) monoclonal gammopathy of undetermined significance.

Question 5

Which cytogenetic abnormality is associated with an excellent prognosis in children with B-cell acute lymphoblastic leukemia (ALL)?

A) t(12:21)(p13;q22)
B) t(14:18)(p13;q22)
C) t(9;22)
D) Hypodiploidy

Question 6

A patient whose malignant clone is positive for the CD markers CD15 and CD30 is most likely to have what clinical disease?

A) Non-Hodgkin lymphoma
B) Hodgkin lymphoma
C) Acute lymphocytic leukemia
D) Hairy-cell leukemia

Question 7

Which marker is highly specific for hairy-cell leukemia?

A) CD19
B) CD20
C) CD25
D) CD103

Question 8

Which statement regarding myelogenous leukemias is true?

A) They originate from a common colony-forming cell line.
B) They originate from a common myeloid precursor cell.
C) They originate from a common erythroid precursor cell.
D) They originate from a common megakaryocytic precursor cell.

Question 9

Which type of gene is required for cell growth and division but can cause malignant transformation when altered?

A) Tumor suppressor gene
B) Proto-oncogene
C) Anti-tumor gene
D) Immunoglobulin gene

Question 10

A patient's immunofixation electrophoresis shows excessive amounts of free monoclonal light chains.These light chains are referred to as:

A) Bence Jones proteins.
B) precipitated immunoglobulin A
C) albumin.
D) alpha-1 antitrypsin.